Principal Scientist, Translational - Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

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RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

As a translational scientist you will be at the forefront of bridging laboratory research with clinical applications to advance novel Radiopharmaceutical Oncology therapies. You will play a crucial role in supporting project teams by leveraging your expertise in translational oncology research. Your role will involve translating scientific findings into actionable insights that inform clinical development strategies, identify biomarkers, and drive therapeutic innovations.  Your responsibilities will encompass a range of activities from target validation through to clinical development strategy, with a focus on identifying indications, understanding resistance mechanisms, and developing rational combinations. The ideal candidate will be an experienced, accomplished translational scientist with outstanding interpersonal and communication skills. The position will require an ability to work effectively in interdisciplinary team settings. In addition to being a thought leader, this role is expected to provide technical leadership in the lab. The role requires an ability and willingness to work with radioactive isotopes.

*This is an onsite position located at Rayzebio's San Diego, CA office

Key Responsibilities:

• Conduct immunohistochemistry (IHC) analysis to evaluate new targets identified by the project teams. Interpret and present IHC data to guide decision-making on target selection and validation.

• Utilize molecular and genetic tools to identify and validate anchor indications for novel therapies. Analyze clinical and preclinical data to support the selection of lead indications.

• In partnership with a cross functional team leader, provide strategic and operational translational leadership for project teams on specific targets.

• Contribute to the development of translational research strategies aligned with therapeutic goals.

• Lead efforts to develop and execute strategies for generating data in relevant models, discover and validate biomarkers that predict patient response to therapies, to inform clinical trial designs.

• Develop/optimize and utilize preclinical in vivo models that mimic human cancer biology to evaluate drug efficacy, mechanism of action, and resistance mechanisms.

• Integrate biomarker findings into clinical development plans and regulatory submissions.

• Investigate mechanisms of radiosensitivity and develop tools and models to predict response to radiotherapy and identify potential biomarkers.

• Investigate resistance mechanisms and propose strategies to overcome resistance through rational combinations.

• Author/review study reports and regulatory documentation, scientific presentations and publications and manage external research collaborations.

Education & Experience:

• PhD in cancer biology, molecular/cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development.

• 5+ years of translational oncology experience in pharmaceutical/biotech R&D environments demonstrating successful acc