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AD / Director Program Management

Karyopharm Therapeutics
Remote, United States, United StatesRemotefull_timeVerifiedPosted 29 Oct 2025
💰 $275,000/yr($205,000/yr$275,000/yr)

About the role

Role Overview & Key Functions:

As a Karyopharmer, reporting to the Senior Director Program Management, you will positively impact patients’ when you:

 

  • Acts as the COO of Program, partnering with the Program Lead to drive team alignment on program strategy and operationalize the strategic vision
  • Provides an independent voice to shape the program strategy and acts as an integrator of cross-functional input to drive optimal decisions for the program
  • Leads effective Program Team meetings and presents program strategy to various audiences
  • Accountable for the cross-functional execution of one or more program strategy plans. Can be assigned to any disease area, at any stage of development
  • Manages program timeline, cost, quality, and risk mitigation as well as timely escalation where needed
  • Acts as a leader in the PM organization to help build cross-portfolio capabilities. Recognizes consistent challenges and innovates solutions, shares best practices and coaches more junior PMs

Candidate Profile & Requirements:

  • Manages the effective operations of Karyopharm’s cross-functional program teams, focused on the development of one or more disease area programs
  • Partners with the Program Lead to drive development of the Program Strategy Plan, adding value by deriving insights from cross-functional discussions and summarizing those insights in a plan that can be easily communicated and implemented across the enterprise
  • Partners with the Program Lead to coordinate the development, and implementation of high quality, global, cross-functional, integrated project plans that are aligned with the program strategy
  • Fosters a high-performing team by championing team norms, operating principles and introducing best practices. Monitors the heath and operating efficiency of the team on a regular basis and shares feedback
  • Mentors and coaches team members to drive accountability, alignment, and excellence
  • Facilitates effective business decisions by ensuring integration of key cross-functional input and robust analysis of scenarios. Ensures all decisions are assessed as to their impacts and communicated to stakeholders in a transparent and timely manner
  • Highlights key interdependencies and downstream impacts of strategic decisions to stakeholders
  • For programs that are being jointly developed, works closely with alliance management and partner counterparts to ensure appropriate level of engagement in program strategy discussions   
  • Responsible for maintaining and updating program dashboards for assigned program team(s), provides regular status reports on key deliverables, risks and issues to Program Lead
  • Proactively coordinates risk management and ensures contingency and/or risk mitigation plans are developed
  • Works with functions to procure adequate resources to achieve project objectives in planned timeframes
  • Acts as a change agent and leads process improvement initiatives for continuous improvement and as it relates to improving project delivery
  • May delegate project level tasks/follow-up and provides oversight to Project Manager(s) with potential for direct reporting responsibility
  • Works creatively and analytically in a problem-solving environment demonstrating teamwork, innovation, and excellence

 

QUALIFICATIONS:

  • Bachelors degree in a science related or business related field required. Advanced degree preferred (e.g., MBA, MS, PhD, PharmD).
  • Five (5) or more years of demonstrated drug development project/program management experience with 7+ years of relevant experience in the Pharmaceutical or related Life Sciences industry.
  • Strong knowledge in drug discovery and development and/ or clinical research or related health sciences field with solid understanding of project strategy, interdependencies, and disease content to contribute to strategic discussions
  • Experience with operational study start-up into Registrational/Phase 3 trials with a deep understanding of the necessary steps required for market application submissions in multiple regions (US, EU, Japan, China)
  • Well-developed program leadership and strategic thinking skills, experience in development of Program Strategy Plans
  • Experience in partnering with functional leads across the organization to meet strategic goals and demonstrated ability to collaborate in a cross-functional environment
  • Excellent organizational skills ability to manage several priorities simultaneously
  • Ability to influence without authority and to act as a leader on a wide range of complex activities where judgment and expertise are critical to project success
  • Strong communicator able to integrate information and tailor messages to aud

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Company

Karyopharm Therapeutics

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