Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

<p><strong><em> </em></strong><strong><em>Company</em></strong></p> <p><em>Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.</em></p> <p><em> </em><strong><u>Position</u></strong></p> <p>Nurix Therapeutics is searching for a motivated <strong>Research Associate</strong> to join our <strong>Bioanalytical-In Vitro DMPK</strong> team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving <em>in vivo</em> and <em>in vitro </em>studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments.  The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all <em>in vitro</em> and <em>in vivo</em> studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.</p> <p><strong><u>Key Responsibilities<br></u></strong></p> <ul> <li>Provide bioanalytical support for in-house PK, non-GLP safety TK</li> <li>Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis</li> <li>Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples</li> <li>Conduct in-vitro stability assays to understand metabolism of drugs</li> <li>Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation a