Associate Director of Real-World Evidence & Observational Research

We are seeking an Associate Director of Real-World Evidence & Observational Research to drive the execution of real-world evidence initiatives for our early cancer detection portfolio. This role is central to generating the evidence needed to support product adoption, inform clinical use, and demonstrate value to physicians and payers.

As a seasoned clinical research professional, you will contribute to both the strategy and execution of observational research across a defined product area. You will serve as the internal subject matter expert for RWE methodologies and execution—partnering across Clinical Science, Medical Affairs, Product, and Market Access to translate key questions into actionable evidence.

This is a highly cross-functional, hands-on role requiring strong scientific judgment, operational ownership, and the ability to balance rigor, speed, and business impact.

 

 

PRIMARY RESPONSIBILITIES

Lead Real-World Evidence Strategy & Execution

• Lead the design and execution of real-world evidence studies, including retrospective database analyses and prospective observational studies

• Contribute to clinical evidence strategy for a defined product area, identifying where RWE can address key evidence gaps

• Translate clinical, scientific, and business questions into robust, decision-oriented study designs

• Proactively identify risks to study execution and implement mitigation strategies

• Lead to protocol development, including objectives/endpoints, eligibility criteria, data collection approaches, and analysis plans

• Partner with biostatistics and data science to ensure high-quality data analysis, interpretation, and reporting

• Drive medical data review, interpretation, and synthesis of findings

Turn Evidence into Decisions

• Deliver clear, actionable insights that inform product strategy, clinical positioning, and market access

• Evaluate real-world product performance and identify opportunities to improve adoption, utilization, and outcomes

• Partner with Product and Medical Affairs to ensure real-world insights are fed back into product development

Shape and Prioritize Evidence Generation

• Contribute to evidence planning by identifying where RWE can most effectively address key gaps

• Support prioritization of studies based on business impact, feasibility, and timing

• Ensure alignment between RWE, clinical studies, and broader evidence generation efforts

Enable External Impact

• Support development of publications, abstracts, and presentations to communicate evidence externally

• Partner with Medical Affairs and Market Access to translate evidence into compelling narratives for clinicians, KOLs, and payers

 

Required Qualifications

• Advanced degree (PhD, MPH, MS, PharmD, or equivalent) in epidemiology, health outcomes research, biostatistics, or related field

• 7–10+ years of experience in real-world evidence, observational research, or HEOR, ideally in industry

• Demonstrated experience leading the design and execution of observational studies across the full lifecycle (protocol through analysis and dissemination)

• Strong understanding of real-world data sources (claims, EHR, registries) and their application to clinical and business questions

 

Preferred Qualifications

• Experience in early cancer detection

• HEOR experience

• Experience working cross-functionally with product, medical, and commercial teams

• Track record of translating analyses into business-relevant insights (not just publications)

 

Key Competencies

• Strong scientific and operational judgment across the full clinical evidence lifecycle

• Ability to independently lead complex projects with limited oversight

• Skilled at balancing scientific rigor, speed, and resource constraints

• Effective at influencin