Senior/Principal Scientist, Immune Cell Biology

Company Summary:

FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

We are searching for an experienced and enthusiastic Senior/Principal Sci to lead efforts characterizing nucleic acid function, localization, and responses in immune cells. We are looking for an individual who enjoys hands-on laboratory benchwork and brings scientific rigor and intellectual curiosity to their role. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team. 

Key Responsibilities: 

• Conception, design, execution, and troubleshooting of functional T cell assays
• Strong background in immune cell biology: in vitro cell lines and donor derived T/APC cells, stimulation, proliferation, nucleic acid delivery and resulting innate response, gene-editing, and cell-state characterization
• Utilize a deep understanding of immune cell biology to screen nucleic acid function at both the cellular and molecular level
• Employ a deep understanding of CAR function and immune cell fitness to advance cell therapy projects in vitro and in vivo
• Proficient at analysis of nucleic acid function (Flow-cytometry, Incucyte, microscopy, qPCR, HiBit/luciferase, Cre/lox, etc)
• Track record of solid managerial experience and scientific leadership
• Effectively communicate experimental methods and findings in both oral and written formats 
• Maintain a workload of multiple concurrent projects and rapidly adjust experimental priorities to align with company priorities
• Comfortable working both independently and collaboratively in a multidisciplinary team environment

Qualifications: 

• Ph.D. in Biology, Immunology, Virology, or related field with 3-6 years of industry experience
• Broad experience in cellular biology, immunology and virology, particularly as relevant for the functionalization of nucleic acids in the context of immune cells
• Experience with CAR-T design and assay development is a bonus: cancer cell killing, receptor density characterization, etc
• Enthusiasm for working at the bench 
• Strong communication and interpersonal skills 
• Strong organizational, analytical, and problem-solving skills 
• Interest in developing new skills 
• Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment 

More About Flagship Pioneering

We are creative optimists and we would love for you to consider joining our team!  See all our open opportunities across Flagship Pioneering’s Ecosystem!

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at