Research Associate, RNA Production Research Optimization (P.R.O.)

Orna Therapeutics is an innovative biotechnology startup based in Watertown, MA, committed to developing groundbreaking therapies for diseases that current approaches cannot address. With our pioneering circular RNA technology, developed at MIT, we are at the forefront of advancing the next generation of RNA therapeutics. Our state-of-the-art expression and delivery platform positions us to tackle complex diseases, including B cell-driven autoimmune disorders, B cell malignancies, sickle cell disease, and beyond.

We are seeking an exceptional Research Associate or Senior Research Associate to join our team - RNA Production, Research, and Optimization (P.R.O.). This position will report to a Senior Scientist and focus on small-scale RNA synthesis/optimization, purification, and characterization. An ideal candidate would have hands-on experience with high-throughput and/or automated workflows for molecular biology. This position will require one who learns and adapts quickly, follows established protocols, and is comfortable in a dynamic and collaborative environment. The candidate will be expected to document all experiments in detail and share results both orally and in writing.

Responsibilities

• Development of in-vitro transcription (IVT) conditions and purification processes for circular RNA based therapeutics to support various programs.
• Learn and apply high-throughput techniques to RNA synthesis, such as programming and operating liquid handlers to perform 96-well screens.
• Optimize reactions, starting materials, and process conditions.
• Contribute to downstream process development for purification of circular RNA.
• Develop analytics for purity determination and impurity profiling.
• Document experiments and summarize results in an electronic lab notebook in an organized manner.
• Responsible for hands-on assistance with good lab practices (i.e. inventory creation and maintenance; lab organization and safety compliance; equipment tracking, maintenance and service issues; etc.)

Qualifications

• B.S./M.S. in Chemical Engineering, Chemical Biology, Biomedical Engineering, Chemistry, Bioengineering, Biochemistry, Molecular Biology, or a related field with understanding of RNA structure and function.
• Working knowledge of RNA process analytics.
• Working knowledge of analytical or preparative chromatography.

Why Orna? At Orna Therapeutics, we’re more than just a workplace—we’re a community. We believe in fostering an environment where individuals can grow, thrive, and make a lasting impact on the future of healthcare. Join us as we revolutionize RNA therapeutics and make a difference in the lives of patients around the world.

Equal Employment Opportunity Statement

Individuals seeking employment at Orna Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.