Senior Scientist - Onsite - Marlborough, MA

To drive the creation of new innovative biomanufacturing solutions, Sartorius has formed an initiative to discover new trends and cutting-edge opportunities for rapid conversion towards next-generation continuous and integrated closed manufacturing solutions. This exciting initiative enables the research, process development, and clinical production of novel modalities using next-generation manufacturing platforms, in partnership with key customers.

Sartorius’ Process Development Services team in the Greater Boston (MA) area is a part of the Corporate Research Group and is engaged in the design, development, and optimization of cell and gene therapy manufacturing processes that can be transformed from early pre-clinical stage into cGMP ready manufacturing scale. The incumbent is expected to work closely together with an internal multi-disciplinary product development team, to create forward-looking processes that provide a basis for commercial manufacturing that can be integrated into our process solution offering.

What you will accomplish together with us:

• You will develop, and scale up manufacturing processes for LNP production for a wide variety of LNP compositions and cargos
• One of your tasks will be to establish critical process parameters that enable successful manufacturing process scale-up
• In this role, you will identify critical quality attributes for successful LNP production and develop assays to measure these CQAs
• You will lead multiple high impact internal and external research projects by establishing priorities, milestones, schedules, and deadlines.
• You will develop and write process development proposals, conduct hands-on laboratory work to optimize and troubleshoot upstream and downstream manufacturing processes for novel LNP formulations
• As the Senior Scientist, you will be responsible for writing, reviewing, and maintaining electronic lab notebooks with the highest level of research integrity.
• You will be responsible for writing project reports, briefs, protocols and making presentations to internal and external partners and project teams as required.
• One of your tasks will be to participate in technology transfer activities to internal and external collaborators.
• Support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.
• Conduct technical investigations and risk assessments related to manufacturing processes.
• Support generation of protocols, work instructions, batch records and reports.
• Work independently in a matrixed environment.
• Perform occasional extended hours and weekends to support ongoing lab activities as needed.
• Mentor and support junior staff and build a culture of support and collaboration.
• Comply with all site policies such as record retention, ISO requirements, and accountable for good housekeeping in all laboratories.
• Comply with biohazard, special clean room and site safety/health procedures and guidelines as required.
• Assist other team members and site management team with miscellaneous duties when requested.

What will convince us:

Education:

• MS (with 2+ years of industry experience) or PhD in chemical, biochemical or biomedical engineering, engineered cell therapies or related field.

Experience:

• Knowledge of current developments in LNP formulation and characterization.
• Knowledge of current developments in genome editing and gene delivery technologies.
• Experience & knowledge of state-of the-art upstream and downstream technologies for LNP process development workflows.
• Ability to interface with specialists from target biological application areas and engineering disciplines such as mechanical (hardware, fluidic, thermal), electrical, software, sensor technology (optical, electronical), and chemical.
• Experience working as part of collaborative R&D project team.
• Strong analytical and mathematical ability.
• Ability to work independently and constructively in a team environment.
• Must have strong personal initiative and be result oriented.
• Strong troubleshooting skills
• Strong written and verbal English communication skills, capable of clearly expressing technical concepts to people with various levels of technical expertise and diverse cultural backgrounds.
• Travel ~ 10-20% of time, both foreign and domestic. Work on weekends as required. Work in a Biosafety Level 2 Laboratory.
• Identification with our core values: Sustainability, Openness, Enjoyment

What We Offer

As a growing global life science company, with our stock listed on the German DAX and TecDAX , Sartorius offers a wide range of benefits: