Principal Systems Engineer II

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

Roche Diagnostics develops and produces medical tests and digital tools that provide information to help healthcare professionals find the right treatment for patients and deliver the best patient care to improve, prolong and save lives.  

Roche Sequencing Solutions is developing new technologies to make genetic testing easy, reliable, and affordable.  The team is seeking a passionate Engineer to join our Systems Integration Group to support the Next Generation Sequencing (NGS) products. This is a hands-on role; you will be a key contributor in the feasibility, development, and integration phases of end-to-end NGS solutions. As a team member on the Systems Integration team, you will learn to use the Roche Single Molecule Sequencing platform to optimize the final operating protocols while designing & performing wet-lab experiments to further develop the sequencing solution through integration of subcomponents and optimization of the entire system.  

• You will Interpret the experimental results, proper experimental design, and become an expert on Single Molecule Sequencing. 

• You will perform a variety of sample prep, library, or sequencing related experiments & verification studies. 

• You will complete all work using best laboratory practices and maintain a well-organized and concise record of work performed and progress made. 

• You have demonstrated experience for troubleshooting instrument failures with standard root cause methods while engaging with SMEs to understand failure modes. • 

• You understand product requirements in order to develop, execute, and document test cases for verification and validation.   

This position is located on-site in Santa Clara, CA. This is not a hybrid position.
Relocation benefits will not be provided. 

Who You Are: 

(Required) 

• You hold a Bachelor’s Degree in chemistry, science, engineering and/or other related field with 7 or more years of experience; or a Master’s degree (in the above listed areas of study) with 5 or more years of experience; or a PhD (in above listed areas of study) with 3+ years of experience. 

• You have demonstrated hands-on experience with PCR, DNA sequencing methods such as raw sample preparation, nucleic acid extraction, library preparation, and NGS sequencing.  

• You have a 5 or more years of experience with MATLAB, GIT, Python or similar tools for data analysis and/or automation; experience with statistical tools (e.g. Python/JMP for regression analysis, ANOVA)

• You have 7 or more years of experience in Design of Experiments methodology; and application of statistical process control 

Preferred:
 

• You have a proven track record of leading and performing in a fast-paced, matrix environment; ability to work independently and influencing others with strategic decisions 

• You have experience leading and mentoring others; demonstrated collaborative experience 

• You have experience solving unique or unpredictable problems that might have an impact on the goals and objectives as set by the organization 

• You are adept at planning, prioritizing, multi-tasking, and following through, while remaining highly energetic and focused 

• You have demonstrated interpersonal skills: Strong interpersonal, verbal communication and influencing skills: can influence without authority and has proven experience building  and cultivating relationships with key partners and stakeholders, both internally and externally  

This position is based onsite in Santa Clara, CA. This is not a hybrid position.

Relocation benefits are not available for this job position. 

The expected salary range for this position based on the primary location Santa Clara, CA is $103,600 - $236,500.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-relat