Principal Quantitative Scientist

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The Position

A healthier future is what drives us to innovate, to continuously advance science, and to ensure everyone has access to the healthcare they need today and for generations to come.

As a Principal Quantitative Scientist, you are responsible for leading, conceptualizing, planning and executing advanced real-world data (RWD) projects to generate evidence in support of the CDS portfolio, clinical tests, diagnostic devices, and services developed and marketed by Roche Diagnostics, leading to better and more efficient patient care. You will contribute to broad product support initiatives and/or studies, lead and deliver on complex projects, and interact with external partners without supervision.

The data you will be working with are varied in type, including, but not limited to, clinical patient-level data, supplemented with data such as omics, imaging, digital health, etc. You will lead and collaborate with peers within the function and across the organization to develop and improve existing strategies, CDS and workflow solutions, improve product support strategies, identify evidence gaps and data sources, design and execute studies, implement analyses to support improvement of existing products, and lead discovery and early development of new features or apps to drive the NAVIFY portfolio as well as Diagnostics clinical tests, devices, and services. You will be able to quantify the value of these products from both a patient outcome and business value, as well as from a regulatory perspective. You will drive the creation of best practices and share learnings/experience with colleagues both internal and external to the function to shape the use of RWD and implement sustainable, science-based practices in Diagnostics.  

The Opportunity:

In this position, you will also ensure that the design, execution, and presentation of evidence adhere to the highest scientific standards. To succeed, you will leverage your expertise and expand your knowledge of available healthcare data sources and applicable state-of-the-art methodologies. Hands-on experience with large-scale processing and visualization of RWD through various languages and tools (e.g. R, Python, (no-)SQL, Spark, etc.) is required. In addition, you will rely on your scientific expertise and your ability to interact and influence cross-functional experts such as clinical biostatisticians, data scientists, and product owners to discover novel insights demonstrating the impact of various treatment decisions and uncover key elements leading to the best outcomes for patients. 

This role is hybrid with a physical presence at one of the following Roche campuses: [Indianapolis], [USA].

Responsibilities include:

• Provide RWD leadership for evidence generation using RWD, supporting In-Vitro Diagnostics (IVD) and CDS product portfolio at Roche Diagnostics. 

• Drive the primary strategic and operational responsibility for the design, execution, and reporting of RWD studies using a variety of available research and commercial healthcare databases.

• Identify and establish collaborations with healthcare institutes expanding sources of available RWD sources. 

• Work closely with product leads, clinical development, clinical operations, and medical affairs directors across Roche Diagnostics to create, confirm and validate disease & clinical hypotheses for RWD projects supporting commercial, market access, medical and regulatory needs.

• Promote the increased adoption and use of RWD to supplement clinical study design and execution, and identify opportunities where RWD could be the primary evidence generation mechanism to achieve regulatory and reimbursement objectives for IVD and CDS products being developed across Roche Diagnostics.

• Develop RWD study protocols and lead analysis projects supporting evidence needs of IVD and CDS product portfolio. Collaborate with internal and external partners (e.g., key opinion leaders, academic institutions, CROs) on the design and implementation of RWD studies.

• Lead RWD analysis projects from start to completion.

• Ensure high quality r