TEMP- Associate Scientist / Scientist, Bioanalytical LC-MS

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

The successful candidate will be responsible for developing, optimizing, and implementing LC-MS bioanalytical methods to support the quantitative analysis of small molecules, peptides, and proteins in biological matrices. This position also involves working collaboratively with cross-functional teams to support drug discovery and development programs.

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Your Contributions (include, but are not limited to):

• Develop and execute LC-MS/MS bioanalytical methods for the quantification of small molecules, peptides, and proteins in biological samples from preclinical Pharmacokinetic and Toxicokinetic studies

• Proficiency in sample preparation techniques for biological matrices, such as solid-phase extraction, protein precipitation and affinity purification

• Strong expertise in LC-MS/MS method development, optimization and troubleshooting on Triple Quadrupole (Sciex or similar) or Orbitrap HRMS

• Perform Pharmacokinetic analysis and modeling using Phoenix Winnonlin

• Collaborate with cross-functional teams to support preclinical studies by providing bioanalytical support and data interpretation.

• Contribute to the preparation of bioanalytical protocols and study reports

Requirements:

• BS/BA degree in analytical chemistry, biochemistry, pharmaceutical sciences, or related discipline and 2+ years of pharmaceutical industry experience OR

• MS/MA degree in chemistry or closely related field preferred and some similar industry experience noted above OR

• PhD in chemistry or closely related field and some industry or relevant experience a plus

• Hands-on experience in bioanalytical method development for various therapeutic modalities using LC-MS/MS

• Excellent communication and interpersonal skills, with the ability to work effectively in a collaborative team environment

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