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Senior Scientist, Ex Vivo Systems and Assay Development
Gordian BiotechnologySouth San Francisco, United Statesfull_timeVerifiedPosted 31 Oct 2024
About the role
Are you ready to play a pivotal role in critical ex vivo validation experiments and research activities to support Gordian’s development of novel drug candidates?
We’ve shown that our platform predicts preclinical and clinical physiological responses from in vivo Mosaic screens. You’ll be at the center of a fast-paced team of scientific experts using our platform to run discovery screens for more therapeutic targets than ever before, in the most realistic models of disease!
The Destination:
Gordian Biotechnology is a therapeutics company whose mission is to cure age-related diseases and ultimately allow people to lead longer, healthier lives.
Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment.
To address this problem, Gordian’s platform is the first and only to enable pooled in vivo tests at scale in our proprietary “patient avatars”. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to cover every therapeutic target at the beginning of the drug discovery process (more info on our website). We can choose targets that really impact disease biology, to develop and commercialize therapies for the world’s deadliest diseases, and eventually for the processes of aging itself.
The Journey:
Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability.
Team – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help.
Extraordinary – Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return.
Like any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. This year, in accordance with our unlimited vacation policy, each member took an average of 4.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design.
If this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be.
You can dive deeper here.
About the Role:
Your primary mission as Senior Scientist, Ex Vivo Systems and Assay Development will be to design, execute, and optimize ex vivo experiments that validate key targets from our screening platform. You will work with therapeutic leads across pulmonary fibrosis (PF), heart failure (HF), and MASH programs to set up and refine complex human tissue models, facilitating early validation or elimination of therapeutic targets. You will take ownership of ex vivo cultures, developing assays that evaluate safety, efficacy, and mechanisms of action, ensuring target validation occurs with precision and speed. Additionally, you’ll collaborate with our disease biology heads to enhance workflow processes, establish SOPs, and help streamline data-driven decision-making. Your focus at Gordian is for the validation or elimination of screen hits to happen as early as possible. Gordian is unique in that our in vivo discovery delivers results at a far greater scale than even
We’ve shown that our platform predicts preclinical and clinical physiological responses from in vivo Mosaic screens. You’ll be at the center of a fast-paced team of scientific experts using our platform to run discovery screens for more therapeutic targets than ever before, in the most realistic models of disease!
The Destination:
Gordian Biotechnology is a therapeutics company whose mission is to cure age-related diseases and ultimately allow people to lead longer, healthier lives.
Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment.
To address this problem, Gordian’s platform is the first and only to enable pooled in vivo tests at scale in our proprietary “patient avatars”. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to cover every therapeutic target at the beginning of the drug discovery process (more info on our website). We can choose targets that really impact disease biology, to develop and commercialize therapies for the world’s deadliest diseases, and eventually for the processes of aging itself.
The Journey:
Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability.
Team – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help.
Extraordinary – Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return.
Like any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. This year, in accordance with our unlimited vacation policy, each member took an average of 4.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design.
If this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be.
You can dive deeper here.
About the Role:
Your primary mission as Senior Scientist, Ex Vivo Systems and Assay Development will be to design, execute, and optimize ex vivo experiments that validate key targets from our screening platform. You will work with therapeutic leads across pulmonary fibrosis (PF), heart failure (HF), and MASH programs to set up and refine complex human tissue models, facilitating early validation or elimination of therapeutic targets. You will take ownership of ex vivo cultures, developing assays that evaluate safety, efficacy, and mechanisms of action, ensuring target validation occurs with precision and speed. Additionally, you’ll collaborate with our disease biology heads to enhance workflow processes, establish SOPs, and help streamline data-driven decision-making. Your focus at Gordian is for the validation or elimination of screen hits to happen as early as possible. Gordian is unique in that our in vivo discovery delivers results at a far greater scale than even
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