Principal Research Scientist II: Rheumatology

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

We are seeking a highly accomplished scientist to join our Rheumatology team in AbbVie's Immunology Discovery Research organization. Our mission is to lead patient-centric drug discovery efforts in autoimmune diseases, enhancing the chances of successful clinical therapies. In this role, the Senior Principal Research Scientist will oversee a team conducting both in vitro and in vivo pharmacological research to identify and validate new therapeutic targets, as well as to drive projects through the discovery phases into GLP tox and first in human studies.

The candidate’s responsibilities include managing a diverse team of scientists to design and execute in vitro and in vivo studies using current assays and developing novel assays to evaluate target hypotheses and disease biology. These studies will focus on rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other rheumatological conditions. The team will devise strategies to identify new targets for underserved patient populations by leveraging mechanisms and pathways identified through molecular profiling of patient bio-samples. Additionally, they will create human-based assays that reflect disease biology, aiding the characterization of potential novel therapeutic modalities.

The ideal candidate will possess experience in project conception, strategic planning, and leadership within cross-functional, matrixed team environments. They should exhibit profound expertise in immunology and autoimmune disease biology, coupled with a thorough understanding of in vitro cellular and in vivo assay development. Familiarity with techniques such as flow cytometry, ELISA, cell-based assays, and molecular approaches is crucial.

A robust background in drug discove