Sr. Scientist of In Vivo Pharmacology

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.  

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking Sr. Scientist, In-Vivo Pharmacology as part of the Research and Early Development team based in Philadelphia, PA. 

Role Overview

This position will perform preclinical in vivo pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology and in vivo studies with mouse and NHP to assist preclinical cell therapy studies from discovery to first-in-human trials. The successful candidate will work in a collaborative environment and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

Key Responsibilities  

• Conduct in vivo studies with mice and NHP; Interact with CROs for in vivo study related activities
• Interact with research teams for collaboration
• Process and analysis of tumor samples and tissues from mice and NHP
• Acquire, analyze, summary, review and present data
• Participate in assay development and qualification
• Maintain good documentation in ELN, paper notebook and log books.
  
• Perform additional exploratory and investigational studies with various techniques

Requirements

•  Ph.D. or Master degree in biological sciences (Immunology, cell biology and cancer biology) or related area is required
  
• Extensive hands-on in vivo study experience (5+ years) is required, including various injections, bleeding, tissue collection, processing and in vivo imagining. Excellent mice tail vein intravenous injection is a must-have skill.
• Extensive experience in execution of functional-based and multi-color flow cytometry based immune cell analysis is required.
• Prior experience in CAR-T/NK cell therapy is preferred.
• Strong critical thinking and problem-solving skills
• Sense of ownership and integrity of their work.
• A demonstrated ability to work as part of a team
• Demonstrated organizational skills including but not limited to attention to detail and multitasking
• Biotech or pharmaceutical industry experience is preferred.

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The anticipated base pay range is:$123,605—$162,232 USD

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives