Senior Principal Scientist, Oncology Translational Biomarker Lead

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA.

Position Responsibilities:

In this role as Senior Principal Scientist, Translational Biomarker Lead, within the TME TRC Translational Development team, the ideal candidate:

• Designs, develops, establishes, and executes well-crafted asset-level oncology translational plans and biomarker strategies for First In Human through Proof of Concept studies within the TME TRC, focused on mechanism of action, target engagement and pharmacodynamic biomarker assays and potential clinical trial patient stratification and selection assays.

• Accountable for creation and analysis of the assay development and clinical sample analysis plans, budgets, and data, such as generating qualification/validation plans and study reports, developing SOPs, reviewing qualification/validation reports, and contributing to, and reviewing all, pertinent documentation for assigned programs in collaboration with relevant internal subject matter experts

• Effectively partners within a highly matrixed organization within the Translational Development group, within the TME TRC, with oncology program colleagues & with external partners to deliver high-quality biomarker data and drive the advancement of therapeutic candidates.

• Integrates discovery, translational research and other relevant assay information and data, along with logistics and quality considerations, to inform highly complex ideas, activities, and projects.

• Accountable for providing scientific input and biomarker expertise across all aspects of early development plans and collaborations (such clinical protocols, sample collection tables, sample collection instructions and logistics, scopes of work, data transfer agreements, validation reports, study reports, central lab logistics, posters, publications, investigator brochures, INDs, regulatory documents, etc.)

• Progresses translational plans into implementation and execution via leading Translational Subteams, monitoring and tracking assay and analysis status and deliverables, via collaboration with internal technical assay execution and/or execution with external contract research organizations (CROs) and/or specialty testing laboratories

• Supports due diligence, collaboration and asset integration activities as needed

• Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making.

• Provides oversight to progress validated biomarkers into development of diagnostic assays, as needed

• Participates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forums

• Develops solutions and courses of action for senior staff, including identification of risks and risk mitigations

• Shares expertise, experience, lessons learned