Senior Scientist, Analytical Research & Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, based in Boston, Massachusetts, is a clinical-stage company. The company focuses on developing one-time gene editing medicines for cardiovascular disease. Founded by leaders in cardiovascular medicine, human genetics, and gene editing, Verve aims to replace treatment paradigm from chronic diseases management to novel ‘once and done’ single-course gene editing therapeutics. The company’s advanced development programs – VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease.

Lilly seeks a Scientist/Senior Scientist with proven research skills and experience in cross-functional teamwork to join the Analytical Research and Development (ARD) team within Lilly Research Labs focused on Verve Therapeutics’ pipeline. The ARD team at Verve uses advanced biophysical methods to analyze drug substances and drug products supporting our programs. Help us expand the scope of what gene editing can accomplish by tapping into your expertise in protein biochemistry, cell culture, and high-throughput screening of functional attributes of proteins. We use pioneering methods and equipment to design, manufacture, and evaluate novel proteins. A passion for protein and nucleic acid biochemistry, and motivation to develop new techniques and biophysical methods, is crucial. The successful candidate will be encouraged to eventually design and take ownership of their own projects.

Responsibilities 

• Design and generate DNA constructs for protein expression in both bacterial and non-bacterial systems.
• Express, purify, and characterize proteins using LC-based techniques.
• Design and develop assays for the structural-functional assessment of proteins.
• Design and develop analytical assays for protein characterization.
• Perform routine cell culture and in vitro cellular assays to evaluate gene editing materials.
• Work with teams across process development, formulation, and preclinical research to support various programs.
• Write method development protocols; perform experiments; organize, analyze, plot and interpret data; and document work in an electronic lab notebook.
• Summarize results in presentations and technical reports for internal teams/ collaborators.
• Support laboratory operations by preparing reagents, ensuring instruments are properly maintained, ordering necessary supplies, and following all environmental, health and safety regulations to keep the laboratory safe, efficient and organized.   

Basic Skills & Qualifications 

• Masters in Biological Sciences, Protein Biochemistry or a related field
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Skills/Preference 

• Hands-on experience with CRISPR-based gene editing, mRNA and editor protein design and synthesis, cell culture, and understanding of protein structure-function relationships.
• 3+ years of academic or industry lab-based experience in protein expression, purification, and evaluation of protein purity and structure-function assessment.
• Hands-on experience in SDS-PAGE, FPLC, IEX/IPRP/SEC chromatography, ELISA, Western blots, protein and peptide mass spectroscopy, and BLI