Sr. Scientist, DMPK

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

As a DMPK senior scientist within Preclinical Development, a successful candidate will execute and manage in vitro DMPK studies to support product advancement from early discovery through commercial.

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Your Contributions (include, but are not limited to):

• Execute in vitro DMPK studies to identify potential new drug candidates and support the development of clinical-stage drug candidates

• Manage in vitro DMPK studies conducted at CROs

• Research and implement new technologies as needed

• Present updates at department and project team meetings

• Source, procure, install, qualify, operate, and maintain instrumentation and equipment required for in vitro DMPK studies, as needed

• Must have a solid understanding of the objectives and underlying science of in vitro DMPK studies

• Perform other duties as assigned

Requirements:

• BS/BA degree in biology, chemistry, or related science and 5+ years of experience in Biopharmaceutical industry, preferably with experience in an ADME laboratory. Strong experience with DMPK screening models, particularly permeability and transporter model. Experience acting as a DMPK representative on discovery teams.  Hands-on experience with automation, tissue culture, LC-MS/MS or relevant experience required OR

• MS/MA degree and 3+ years of experience as shown above OR

• PhD or equivalent; some experience as shown above may include postdoc experience

• Experience performing in vitro DMPK studies; plasma protein binding, CYP inhibition, CYP induction, metabolic stability, reaction phenotyping, in vitro drug metabolism using microsomes and hepatocytes

• Experience with the following instrumentation and techniques is preferred; LC-MS/MS, HPLC, laboratory automation,  cell culture, use of radioactivity

• Good interpersonal, verbal and written communication skills

• Excellent organizational skills

• Ability t