Senior Research Associate, Analytical Development

Our Analytical Development team is growing and we’re seeking a Senior Research Associate to participate in designing and executing experiments, as well as perform sample analysis utilizing HPLC, CE-SDS, iCIEF, and capillary CE-SDS ELISA [simple western blot (Jess)]. These activities will support CMC, discovery, pre-clinical, and clinical development of existing and new lead candidates. This position will directly support the discovery of next-generation immune oncology drugs. It is a hands-on position that requires effective communication and documentation of results to enable the advancement of novel research molecules toward development of clinical candidates, which will ultimately lead to late-stage development and commercialization. Ideal applicants will be agile and highly driven, collaborative, team-oriented, possess excellent communication and organization skills, and carry a strong commitment to excellence.

Essential Functions and Responsibilities:

• Develop and perform HPLC and UPLC assays with minimal supervision including SEC, HIC, IEX, and RP.
• Develop and perform iCIEF and CE-SDS assays.
• Develop and perform ELISAs.
• Perform DLS/SLS analysis using an UNcle instrument and generate datasets that will be used for formulation development studies.
• Perform subvisible particulate matter analysis by HIAC.
• Perform formulation development studies and execute clinical in-use stability studies, transfer formulation knowledge internally.
• Design, conduct, analyze, interpret, and report laboratory experiments; summarize results for meetings and regulatory filings.
• Write and manage SOP’s and test methods, train colleagues and facilitate method transfer to partners and CDMOs.
• Manage and maintain required reagents, laboratory environment, and equipment needed to carry out assignments.
• Draft development reports, method qualification protocols, and method qualification reports
• Prepare presentations for team meetings.
• Work closely with team leaders to complete highest priority work to reach goals and milestones.
• Other duties as assigned.

Required Skills and Qualifications

• A minimum of a bachelor’s degree and 4-6 years of relevant industry experience or a master’s degree with 3-5 years of relevant industry experience.
• Strong benchtop skills, experience with analysis of protein biologics and peptides.
• Proficient with the development of HPLC and UPLC assays; at least 3 years of experience is required. SEC, RP, HIC, and IEX experience is desired.
• Experience developing and performing ELISAs
• Knowledge and familiarity in employing various analytical techniques, to include but not be limited to: CE-SDS, iCIEF. Experience with DLS/SLS (UNcle), HIAC, HIC and CE-SDS ELISA (Simple Western) blotting or similar technology is desired but not required.
• Experience with formulation development with focus on antibodies or bispecifics is highly desired.
• Ability to perform routine testing and to follow SOPs in a highly accurate and reproducible manner.
• Desire and ability to learn new technologies, thinking outside the box, and exploring new approaches to innovate.
• Training on project specific assays and ability to train others.
• Proven experience with writing and maintaining SOPs, ability to train others and to transfer methods to external partners.
• Ability to work independently; anticipates and solves problems in a proactive fashion.
• Must have excellent computer skills, proficiency with Microsoft Excel and PowerPoint required.
• Good oral and written communication skills a must, excellent team player.

Job Type: Full-time Benefits:·         401K·         Medical insurance·         Dental insurance·         Vision insurance·         Supplemental disability insurance plans·         Flexible schedule·         Life insurance·         Flexible vacation·         Sick time·         Incentive stock option plan·         Relocation assistance Schedule:·         Monday to Friday Work authorization:·         United States (Required) Additional Compensation:·         Annual targeted bonus X% Work Location:·         O