Director, R&D Scientific Engagement Strategy & Operations

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Director, R&D Scientific Engagement Strategy & Operations, is responsible for leading and operationalizing Madrigal’s R&D external scientific engagement strategy. This role has primary accountability for consultant management, advisory board / steering committee / executive committee execution, and planning, organizing, and executing R&D participation in scientific congresses, professional society meetings, and consortia, ensuring all activities are strategically aligned, operationally rigorous, and fully compliant.

The Director serves as the central point of coordination for external expert interactions across R&D, driving clarity of purpose, disciplined execution, and consistent documentation standards. This individual partners closely with Legal, Compliance, Finance, Medical Affairs, Publications, Communications, Commercial, and other stakeholders. Performance ensures that all external engagements reflect the highest standards of scientific integrity and regulatory adherence.

This role requires a decisive operator who can translate R&D priorities into structured external engagement plans, anticipate compliance and reputational risk, and ensure that R&D derives measurable strategic value from its scientific interactions.

Key Responsibilities

Expert Consultant Engagement & External Scientific Interactions

• Serve as the R&D business lead for all external expert engagements, including individual consultants, advisory board members, steering committee participants, and other scientific advisors.
• Own the end-to-end process for external engagements, including scope definition, contracting, fair market value alignment, documentation of deliverables, and payment oversight in partnership with Legal, Compliance, and Finance.
• Manage both one-time and longitudinal consultant relationships, ensuring clarity of objectives, appropriate documentation, and compliant execution.
• Coordinate group meetings with consultants (virtual and in-person), including charter development, agenda alignment, materials review, and documentation of insights and outcomes.
• Maintain visibility into expert roles across R&D (e.g., Principal Investigators, Data Monitoring Committee members, Steering Committees) to ensure coordinated engagement and appropriate role clarity.
• Ensure that expert input is appropriately captured, documented, and communicated to relevant internal stakeholders while maintaining strict adherence to regulatory and company requirements.

Scientific Conferences & Professional Society Engagement

• Lead the strategic planning and execution of R&D participation at scientific congresses and professional society meetings.
• Define clear R&D objectives for each priority meeting (e.g., data dissemination, competitive intelligence, investigator engagement, scientific positioning).
• Develop coordinated attendance plans, identifying appropriate R&D representatives and clarifying roles and expectations.
• Partner cross-functionally with Medical Affairs, Commercial, Regulatory, Corporate Communications, and other stakeholders to ensure aligned external presence and messaging.
• Implement structured debrief and "bring-back" processes to capture scientific, clinical, and competitive insights and translate them into actionable implications for development strategy.
• Oversee budget planning and tracking for scientific meetings and related external activities.
• Ensure alignment of all activities with internal publications strategy.

Compliance & Quality Oversight<