Associate Scientist, Process Development

At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Position Summary

We are seeking a researcher, to join the Process Development team, as Associate Scientist, contributing to the design and execution of studies to develop and optimize clinical manufacturing processes of our portfolio of engineered T cell therapies. Based in Santa Monica, CA, you will report to the Senior Scientist, Process Development.

Responsibilities

• Design and execute experiments to develop and optimize robust and scalable manufacturing processes for manufacture of genome engineered T cell products.
• Conduct detailed characterization studies to understand process and product quality attributes for cell therapy drug product manufacturing.
• Collect and analyze experimental data and create concise reports summarizing findings and recommendations. Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design.
• Collaborate with cross-functional teams, including research/development scientists, manufacturing personnel, and quality control, to ensure seamless technology transfer from process development to manufacturing. Communicate project updates, results, and strategies to stakeholders and team members
• Stay up to date with the latest scientific advancements and emerging technologies in cell therapy process development. Help implement new technologies and methodologies to enhance process efficiency and productivity.
• Maintain accurate and detailed laboratory notebooks and electronic records in compliance with company policies and regulatory requirements. Prepare and review technical documents, including standard operating procedures (SOPs), batch records, and development reports.
• Work in a team environment to meet project timeline and goals.

Supervisory Responsibilities

• Junior associates (as assigned)

Education and Experience

• At least 3 years of demonstrated hands on experience developing production processes for genome engineered primary cells (required) including T cells (preferred).
• At least three (3) years practical experience with Flow Cytometry.
• Hands-on experience performing analytical methods typically used in the manufacture and characterization of biological products.
• Proficiency with Excel or statistical analysis software (JMP, Minitab, Prism, etc.) for analyzing and presenting data.
• Understanding of US/EU regulatory requirements and working knowledge of cGMPs.
• Ability to think critically, analytically and have demonstrated troubleshooting skills based on deductive reasoning.
• Minimum of a BS degree in Immunology, Cell Biology, Molecular biology, Bioengineering or related discipline with 5+ years relevant experience or MS degree with 3+ years' experience.
• Relevant experience within pharmaceutical or biotech industries in cell therapy preferred.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base salary for this position ranges from $97K to $120K. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related experience. If hired, employee will be in an "at-will position" and we reserve the right to modify base salary (and any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Benefits

• Short-term incentive bonus opportunity
• Equity-based long-term incentive program
• 401(k) plan
• Paid vacation and holidays; paid leaves
• Health benefits including medical, prescription drug, dental, and vision coverage.

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