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Principal Software Engineer (Genomics)

Regeneron
United Statesfull_timeVerifiedPosted 23 Jan 2026
💰 $210,000/yr($128,600/yr$210,000/yr)

About the role

SUMMARY:

We are seeking a Principal Software Engineer (Genomics), who can help develop and maintain computational software, tools, and applications to analyze and interpret millions of sequenced and deeply phenotyped human samples. To enable Regeneron to deliver better medicines to patients, we must empower our scientists to efficiently generate and interact with association analysis results from massive human genetics experiments. You will deliver high-quality, production-level, and flexible tools that help scientists perform large scale genomic analysis and explore and interpret their results.  A proven track record of implementing software and pipelines in a cloud-based computing environment (such as Amazon Web Services or Google Cloud Platform) is essential for this role.

As Principal Software Engineer (Genomics), a typical day may include:

·       Design and implement software applications to fit users’ needs based on shifting state-of-the-art genetic analysis methods, opportunities and priorities.

·       Modernize and optimize existing code bases to improve performance and create scalable, portable, unit tested code.

·       Designing and maintaining robust, cloud-based genomic analysis platforms capable of processing petabytes of genomic data.

·       Implementing comprehensive data management solutions that ensure FAIR data principles.

·       Interact with other developers on the team and jointly develop code to address high-priority tasks.

·       Provide user support by answering questions, understanding specific use cases, fixing bugs, and writing documentation.

This role could be for you if you:

·       Have a strong foundation in the current best practices of software engineering.

·       Enjoy developing tools and solving challenging problems to aid scientists in performing creative analysis.

·       Have a proven record of implementing scalable software tools, applications and workflows and in a cloud-based computing environment.

·       Enjoy directly interacting with users to identify and develop solutions for their needs.

·       Skilled in software development and is familiar or has a strong interest in human genetics or computational genomics.

·       Can effectively communicate methods and present code to a variety of technical audiences.

·       Enjoy working in a highly interactive environment with a diverse team of colleagues.

 

To be considered for this role, you must have:

·       At least a Masters degree in Computer Science, Bioinformatics, Biomedical Engineering, or related field with at least 6 years of relevant experience in Computational Biology or a related field. A Doctoral degree in Computer Science, Bioinformatics, Biomedical Engineering, or related field is also encouraged.

·       Extensive experience with cloud computing platforms (AWS, GCP, or Azure) and containerization technologies.

·       Strong background in developing and optimizing high-performance computing solutions for large-scale genomic data analysis.

·       Proven experience with version control systems, CI/CD pipelines, and other modern software development practices.

·       Deep expertise in multiple programming languages (e.g., Python, C++) and experience with genomic analysis tools.

·       Experience building and maintaining databases and API layers is preferred.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location.  In the U.S., benefits may include health and wellness programs (including medical, dental, visi

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Company

Regeneron

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