Senior Director / Director, Program Management

We create shielded stem cell transplants that enable targeted therapies to attack only cancer cells

Every year, thousands of patients with Acute Myeloid Leukemia (AML) and other blood cancers relapse post-transplant with no safe and effective treatment options. Vor Bio’s approach provides the first opportunity to deliver potentially curative treatments post-transplant.

Our novel platform creates a shielded stem cell transplant that is designed to enable multiple modalities and therapies, including Antibody Drug Conjugates (ADCs) and Chimeric Antigen Receptor T (CAR-T) cells, which could potentially be effective against the tumor, but are toxic to normal cells. Vor’s genetically engineered transplant provides a protective shield to the healthy cells and thereby allows the cancer cells to be specifically targeted for destruction.

By shielding healthy cells, Vor Bio is aiming to potentially cure Acute Myeloid Leukemia (AML) and other blood cancers. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

Who We Are Looking For

Vor Bio is recruiting for a seasoned Senior Director/Director of Program Management to lead our clinical stage cell therapy programs. This role demands a strategic, operational, and cross-functional mindset to support our flagship programs, Trem-cel and VCAR33ALLO. Reporting directly to the SVP of Portfolio Strategy and Program Management (PSPM), you will collaborate across research, development, manufacturing, and business functions to establish best practices and strengthen our program management capabilities.

The ideal candidate will be a thought partner for the SVP, thrive in a fast-paced, dynamic, and highly collaborative environment, and have a passion for pioneering first-in-class treatments. You should be ready to embrace new challenges, communicate effectively, think enterprise-wide, and show a strong commitment to advancing our programs from early to late-stage development.

Key Areas of Responsibility

• Strategic Partnership: Collaborate with the SVP of Portfolio Strategy and Program Management and Program Strategy Team (PST) members to define and execute cross-functional strategies aligned with corporate goals.
• Operational Excellence: Work with the Program Strategy Team, clinical development functions, and cross-functional sub-teams to translate program strategies into efficient, executable operational plans aligned with timelines and budgets.
• Program Management: Develop and own program timelines, cross-functional risk mitigation plans, budgets, and Target Product Profiles (TPPs). Drive cross-functional alignment and manage operational priorities.
• Clinical Support: Partner with the clinical development team, including the CMO, to support ongoing and future clinical studies, ensuring integration and connectivity to overall program planning.
• Systematic Planning: Establish and own flexible program timelines, including milestones, interdependencies, reporting tools, communication strategies, and contingency planning. Ensure budget support in collaboration with SVP, PSPM, and finance.
• Team Organization: Plan, schedule, and drive strategic program team meetings, fostering a culture of ownership, accountability, and continuous improvement. Develop high-performing teams. Foster a collaborative team culture where everyone feels highly engaged and confident in sharing their ideas and perspectives.
• Stakeholder Communication: Effectively communicate with internal stakeholders on the status, goals, risks, and mitigation plans of various programs.
• Cross-Functional Collaboration: Build healthy and collaborative relationships with functional experts across the organization. Provide cross-functional program management for development and business functions as needed.
• Strategic Planning: Contribute to organization-wide strategic planning activities, including support for organizational and change management.
• Decision Facilitation: Support informed decision-making at Vor Bio.
• Mentorship: Guide and mentor talent at Vor Bio.
• Function Evolution: Help evaluate and evolve the Portfolio Strategy and Program Management function to set a solid foundation for