UNIV - Post Doc - Department of Neurosurgery

Job Description Summary

The laboratory of Dr. Strickland in the Department of Neurosurgery and Cancer Biology & Immunology at MUSC is recruiting a motivated post-doctoral fellow in the field of central nervous system immuno-oncology. The Strickland lab focuses on targeting immunosuppressive tumor associated macrophage (TAM) as a means of anti-tumor therapy against glioblastoma. The major theme is translating methods of TAM depletion, or reprogramming towards an anti-inflammatory phenotype, into clinical trial in Dr. Strickland’s busy clinical practice. Dr. Strickland’s laboratory leverages syngeneic animal models with high-throughput transcriptomic approaches to elucidate the complex glioblastoma microenvironment and develop targeted therapies. Studies will generally range from single cell/nuclei and spatial transcriptomics/proteomics, functional cell-based assays, mouse models, and human in-vitro cell culture. In this position, you will have the opportunity to develop and lead projects focused on targeting macrophages in glioblastoma with an emphasis on developing a novel target for CAR-T delivery. You will also gain experience and training in transcriptomics/proteomics, pre-clinical study development. As such, the ability to work with mouse models of cancer is essential. A successful post-doctoral research fellow would be expected to conduct high quality research for publication in high impact journals. Fellows would also be encouraged to apply for independent postdoctoral grants. The Fellow would be joining a laboratory with an experienced research technician III.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Regular

Cost Center

CC000986 COM NSGY General CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

0.00 - 0.00 - 0.000

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Duties:

35% - Develop and lead projects using several cutting-edge model systems including TAM depletion, TAM reprograming, and immune competent models of malignancy. Analyze data generated from these studies and prepare manuscript drafts and present at national conferences.

35% - Train in transcriptomics, flow cytometry, adoptive transfer biology, and pre-clinical development and preparation of IND enabling documents. Outcomes will lead to a publishable manuscript.

25% - Perform immunology techniques including ELISAs, flow-based cytokine determination, cellular proliferation, and cytotoxicity assays, conduct collaborative work on multi-institutional grants.

5% - Perform other essential duties as requested. These will include maintain animal colonies, collaborate with DLAR to provide the best animal care, update IACUC and IBC protocols, order supplies for the laboratory.

Additional Job Description

MUSC Minimum Training and Experience Requirements: PhD

Preferred Experience & Additional Skills: Successful applicants will have a Ph.D. or M.D./Ph.D. with substantial hands-on research experience in immuno-oncology. Candidates with prior experience in immunology, immunotherapy, tumor micro-environment, and cancer biology are highly desirable for this position. As this position will involve in vivo mouse models of glioblastoma, experience in techniques such as animal handling, drug administration, multicolor flow cytometry, ELISA, flow-based cytokine determination, cytometric bead array, TCR immune-sequencing, and cell-based bioassays are essential. A familiarity with handling large data sets to investigate immune pathways dysregulated in glioblastoma and immunotherapy-resistant tumors is also desirable. The candidate must be fluent in oral and written English, able to work independently and collaboratively, are well organized, proficient of proper scientific record keeping, be able to analyze and interpret/communicate data in a logical and timely manner. The ideal candidate will also be able to work with the fluctuating schedule of the neurosurgeon PI who commands a busy brain tumor center.

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at