Research Associate I/II, Protein Sciences

Company Summary: 

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts. With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment. We are actively seeking an exceptional protein scientist to join our team and make significant contributions to our pioneering work. 

Ampersand was founded in Flagship’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary: 

Ampersand is currently seeking a highly motivated, passionate, and detail-oriented Research Associate I/II to join our Protein Sciences team. This is a bench facing role and you will be responsible for performing experiments, analyzing data, and presenting data to your supervisor and to cross-functional team in an effective and timely manner. The ideal candidate will have hands-on experience working with mammalian cell culture, protein expression, purification and analytical QC using diverse biochemical methods such as ELISA, SDS-PAGE, Western blotting. This is a unique opportunity wherein the candidate will be responsible to assist multiple novel research projects along with in vitro and in vivo mAb discovery campaigns. The candidate is expected to have strong organizational, interpersonal, verbal, and written communication skills which will enable them to integrate with our highly cross-functional team.

Key Responsibilities

• Express and purify recombinant proteins from mammalian cultures.
• Routinely perform molecular biology techniques such as PCR, plasmid DNA preparation and bacterial transformation
• Execute small- and large-scale protein purifications using immobilized metal affinity, ion-exchange, and size exclusion chromatography.
• Characterize recombinant proteins using SDS-PAGE, WB, protein quantitation, HPLC, ELISA and other biochemical/biophysical assays such as BLI and SPR to determine protein purity and function.
• Capture primary data and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
• Present data routinely to the Protein Sciences group and other Ampersand teams.

Qualifications/Experience

• BS/MS in Biochemistry, Biomedical engineering, or related field.
• 0-2 years of academic or biotech/pharma laboratory experience is desirable.
• Experience with recombinant protein expression and purification using mammalian cell lines is preferred.
• Experience with FPLC systems and with affinity, IEX and SEC protein purification methods is preferred.
• Experience with general in vitro cell culture techniques is preferred.
• Strong organizational and communication skills along with excellent attention to details is a must.
• Enjoys working in a collaborative, fast-paced and quickly changing environment.

What We Will Offer you:

• Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
• A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
• Participation in an unprecedented opportunity to significantly impact the quality of life of patients by developing a targeted approach to delivering therapeutic molecules.
• Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice