Research Associate Non Viral Delivery

About the Department

Dicerna, a Novo Nordisk company, is focused on driving innovation in RNAi (ribonucleic acid interference) to selectively target and silence genes that cause or contribute to disease. Our proprietary GalXC™ and GalXC-Plus™ RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. Established as a Transformational Research Unit (TRU) following Novo Nordisk’s acquisition of Dicerna Pharmaceuticals, Inc. in December 2021, the Dicerna TRU is a unique new organization within Novo Nordisk that brings together the best of both worlds – the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. With approximately 200 researchers, scientists, drug developers and operational staff, we are a team of inventive and entrepreneurial thinkers pushing the boundaries of science to create and drive new RNAi-based therapies for both rare and more prevalent diseases from the bench to the clinic. Together, we are driving change. Are you ready to make a difference?

The Position

The Research Associate in Non-Viral Delivery department is a part of the RNA & Gene Therapy CVP leadership team. In RNA & Gene Therapies, there are four specialized departments: Non-viral delivery, Viral delivery, RNA Technologies and Genome Editing. The Specialist in question is a subject matter expert in design and synthesis of novel non viral delivery systems, contributing to the overall success of RNA & Gene Therapy area in advancing the portfolio and applications of nucleic acid therapies.

 

Relationship

Reports to Senior Director and head of Non Viral Delivery (interim), Later to Team manager.

• Interacts with peers who specialize in non viral delivery manufacturing and characterization
• In vitro and in vivo bioassays and POC studies
• Peers in MAlov, NVD
• RNA> area wide
• External instrument and equipment vendors
• Procurement

 

Essential Functions

• As a Research Associate in the Non-Viral Delivery department, you will become a part of a multinational and diverse team consisting of fellow Laboratory Technicians, Specialist/Scientists and a global department manager. The goal of the team is to develop synthetic/non-viral nanomedicines, apply advanced analytical characterisation techniques and translate these to preclinical and clinical studies through internal and external collaborations
• Routinely formulate and characterize LNPs at small to mid scale using microfluidics
  • Development and establishment of capabilities for research grade formulation of nucleic acid cargo using a lipid nanoparticle approach
  • Develop robust analytical methods and bioassays for LNP
  • Support organic synthesis and QC of novel biomaterials

• Communicate findings internally to team via presentations and written reports
• Independent planning, execution, and documentation of experiments

 

Physical Requirements

No travel expected.

 

Qualifications

• Bachelors degree strongly preferred with 0 years’ minimum relevant experience required, OR High School Diploma with 8+ years’ relevant experience OR Associate or Vocational degree, 4+ years’ relevant experience may also be considered
• Relevant experience can be a combination of paid and academic experience and should include some of the following:
  • Hands-on experience in handling of DNA, RNA, lipids, and/or polymers
  • Experience with analytical methods, this may include biophysical methods like fluorescence spectroscopy, light scattering, chromatography pH etc.
  • Independently operate good lab maintenance and equipment SOPs etc.
  • Work experience with late stage development and scale up of formulations
  • Experience with automation

 

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

 

At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

 

Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other c