ADS Lead, Early Development

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

This role is in Early Development Biometrics (EDB), a core function within Product Development Data Sciences (PDD) that provides strategic leadership and scientific rigor across early clinical development at Roche. We partner across Biostatistics, Analytical Data Science, and Data Management to enable data-driven decision-making from first-in-human through proof-of-concept studies.

As trusted partners in early development, we design efficient and innovative clinical trials, apply rigorous statistical methods, and implement high-quality programming and analytical solutions to accelerate timelines, de-risk development, and increase the probability of technical success. Our integrated teams operate with agility and scientific depth, supporting exploratory analyses, early regulatory engagements, and complex data-generation needs across therapeutic areas. Together, we bring scientific rigor, technical innovation, and strategic insight to shape the future of early development and deliver better outcomes for patients.

Early Development Biometrics is also home to Methods Collaboration & Outreach (MCO), which enables the most impactful use of quantitative methodology across PDD through internal consultation, external collaboration, and continuous capability building; and Visual Analytics, which creates and maintains interactive dashboards that drive high-quality Medical Data Review (MDR) and safety signal detection, aligned with Risk-Based Quality Management (RBQM) principles and Critical-to-Quality (CtQ) endpoints.
 

The Opportunity: 

The Early Development ADS Lead as a senior leader within the Early Development function, responsible for shaping and executing the analytical data science strategy across multiple clinical programs or an entire therapeutic area. The incumbent leads a team of highly skilled programmers and junior leaders, ensuring the timely delivery of high-quality, regulatory-compliant analytical outputs that underpin key development milestones and health authority submissions.

Beyond overseeing day-to-day operations, this role defines priorities, manages resource allocation, and drives the scalability and sustainability of programming activities through process standardization, automation, and innovation. The role is integral to cross-functional planning and governance, acting as a trusted strategic partner to stakeholders across Product Development Data Science (PDD) and broader clinical development.

As a people leader, this position is accountable for building and nurturing talent, fostering a culture of technical excellence and continuous learning, and ensuring strong alignment with both functional objectives and enterprise-wide data strategies.

• You oversee programming and analytical strategy across multiple early phase molecules or disease area programs, ensuring alignment with clinical hypotheses, translational objectives, and early regulatory needs (e.g., IND submissions, dose selection, go/no-go decisions)

• You lead cross functional planning and delivery of programming outputs for Phase I/II trials, including rapid cycle interim analyses, safety reviews, and exploratory endpoint summaries, while ensuring agility, scientific flexibility, and high quality under accelerated timelines

• You represent Analytical Data Science in early development governance, scientific advisory boards, and early regulatory interactions, helping define data strategy and ensuring programming readiness for evolving study designs and analysis requirements

• You resolve complex technical and operational challenges typical of early development settings, such as integrating diverse data types (e.g., PK, biomarker, imaging), managing high iteration cycles, or handling incomplete or in flight datasets without compromising scientific integrity

• You drive the adoption of flexible, modular programming frameworks and automation approaches, enabling reuse across early trials while maintaining adaptability to frequent design changes, exploratory objectives, and novel endpoints

• You provide oversight and technical leadership for vendor partners, ensuring high quality and timely programming deliverables that align with the fast paced needs of early phase programs and exploratory analysis goals

• You shape the broader Product Development Data Science agenda by representing the early development pr