Jobs and Careers
AS

Head of Portfolio Management R&I - GPPM

AstraZeneca
Gaithersburg, United Statesfull_timeVerifiedPosted 24 Apr 2026

About the role

Head of Portfolio Management, R&I - GPPM

This role can be based out of Gaithersburg, Boston (USA) or Cambridge (UK)

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies.


As a global company in high growth, you will be involved in opportunities across the entire business. And, as we strive to meet our patients’ needs, the priorities will sometimes fluctuate. But it means we are comfortable with change and responding to shifting needs, whilst being mindful of the impact on other projects and roadmaps across the business.


Global Portfolio and Project Management (GPPM) is a global organization of about 250 employees that powers the progression of our pipeline, company strategy and annual business cycle. The focus of the group includes enterprise-wide Portfolio Management, Strategic Planning, R&D Pipeline Project Management, Pipeline Governance (ESPC/LSPC), Data Analytics & Decision Support, Portfolio Systems and Project Information Management. GPPM touches all aspects of project delivery and decision-making across the entire AZ pipeline.

About the Job Role

As the Head of Portfolio Management for the Cardiovascular, Renal and Metabolism (CVRM) TA you will work collaboratively with the Therapeutic Area Leadership team (TALT) to develop and implement the TA Strategy for the CVRM TA team within BioPharma. You will proactively drive strategic engagement with senior leaders across R&D and Commercial to ensure an end-to-end approach from research through early and late-stage development in delivering a compelling and differentiated strategy for our CVRM portfolio, which covers ~50 projects across 6 core areas of focus.


Further you will work to ensure that GPPM delivery - including project delivery, prioritization, scorecard, governance and reporting - are aligned to the SET-endorsed CVRM strategy. You will also report to the VP of GPPM for the BioPharmaceuticals portfolio and will be a member of the GPPM BioPharma LT, ensuring that delivery across GPPM – including portfolio, project management, analytics, systems and governance, support our mission to accelerate and efficiently deliver the AZ portfolio.


In this role, you will have the opportunity to engage and work with key R&D and in line brand teams within the CVRM TA to ensure strategic alignment with AZ portfolio and help ensure readiness for governance reviews and decisions. Excellent cross functional leadership experience and strong influencing skills, as well as an extensive knowledge of drug development and commercialisation is key.

You must be able to represent strategic portfolio thinking across early, late, and in-market assets. Demonstrably strong skills in the areas of strategic thinking, decision making, communication, enterprise leadership, problem solving, influencing and collaboration across both R&D and commercial are crucial. You will be required to understand and apply a broad range of decision making and data analytics tools, plus look at opportunities to optimise ways of working in alignment with the broader enterprise.

Key responsibilities

  • Partners with the cross-functional Therapeutic Area Leadership Team (TALT) to drive development of the overall CVRM strategy for AstraZeneca. Ensures the portfolio is prioritized and scenarios around prioritization, risk and value are considered.

  • Drives development of the strategic components that underpin the TA strategy. This includes evolution of disease or technology specific strategies unique to the TA, new LCM opportunities development, BD opportunity development and support

  • Develops deep understanding of key issues within the TA and ensures the CVRM project and portfolio team effectively uses decision making tools and portfolio assessment/analytics to clarify complex project, product & portfolio issues.

  • Works directly with GPT and commercial brand teams as needed to enhance strategic plans and support portfolio perspective, understanding governance expectations, technical/risk reviews, helping teams to have successful interactions with TALT and corporate governance.

  • Uses TA and wider enterprise knowledge to help drive quality decision making at the TALT. Actively participates during TALT investment decisions.

  • Understands and manages portfolio management systems and tools to enable CVRM to optimize decision making both at the project and portfolio level.

  • Responsible for inputs/outputs for regular portfolio reviews at the TA/Senior Executive Team level. Accountabl

Apply for this role

Generate a tailored application kit with a matched cover letter, interview prep, and CV highlights — in under 60 seconds.

Apply Now →Generate Application Kit

Free account required — sign up in 30s

Company

AstraZeneca

View company profile →