Senior Scientist II, Immunosafety/Immunogenicity

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Purpose

This role will be responsible for evaluating immunogenic risk potential in vitro of candidate therapeutic large molecules and develop novel in vitro immunosafety assays to support development of preclinical molecules.

Key Responsibilities

• Execution of in vitro immunogenicity and immunosafety platform for risk assessment.
• Implement expansion of immunogenicity platform through MHC-II associated peptide proteomics (MAPPs) and real-time DC internalization assay development for large molecules using human DC/PBMC models.
• Represent IVIS team on project meetings, designing & coordinating IVIS studies of biologic drug candidates.
• Author publication, presentations, and/or regulatory documents.

Qualifications

Qualifications

• Bachelor’s Degree and typically 12 years of experience OR Master’s Degree and typically 10 years of experience OR PhD and typically 4 years of experience.
• Ph.D. in Biological Sciences, Cellular Immunology, preferred
• Understanding of cellular immunology with an emphasis on dendritic and T cell biology.
• Experience with multicolor flow cytometry panel design, BD LSRFortessa instrument operation, BD FACSDive and FlowJo software, and flow cytometry data analysis.
• Proven track record with assay development experience successfully handling human samples, isolating cell subsets, maturing antigen presenting cells, and executing proliferation assays.
• Experience with in-silico immunogenicity assessment platforms a plus.
• Excellent interpersonal and oral/written communication skills.
• Results-oriented work ethic a