Principal Scientist

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Summary

Within the Nonclinical Discovery and Development Sciences (NDDS) organization at BMS, the Development DMPK Team provides ADME (absorption, distribution, metabolism, and excretion) and PK (pharmacokinetics) support for all pipeline assets throughout clinical development, from candidate nomination through registration and lifecycle management. The Development DMPK team is responsible for characterizing the ADME properties, and drug-interaction potential of drug candidates. Working closely with drug safety and clinical pharmacology, Development DMPK plays a critical role in IND submissions and marketing authorization applications. We utilize our deep expertise in ADME and PK to collaborate with peer R&D functions to identify and solve issues, enable clinical development and successful marketing authorizations across the globe.

NDDS is looking for a Principal Scientist, Biotransformation to lead biotransformation activities in Development DMPK group that is an expert in ADME, DDI and drug development of all modalities including small molecules, protein therapeutics and novel modalities. The successful candidate will be the subject matter expert and provide strategy/guidance to project teams for advancement of candidate compounds. This job role will focus on hands-on metabolite profiling and characterization of drug candidates in vitro and in vivo to understand metabolic pathways to support drug discovery and development. More broadly, the scientist is expected to integrate this information with absorption, distribution and excretion data for candidate compounds for a full understanding of their drug metabolism and pharmacokinetic (PK) behavior. This role will be based in our R&D headquarters in Lawrenceville, NJ.

Key Responsibilities

• Hands-on biotransformation studies within the Development DMPK group in support of project and portfolio progression.
• Independently design, conduct, troubleshoot and provide oversight of “cold” and radiolabeled in vitro and in vivo preclinical and clinical biotransformation studies for small molecules and new modalities (i.e. peptides, ADCs, AOC/ASO).
• Serve as a biotransformation subject matter expert in dynamic cross-functional team settings, to define strategies to achieve target product profiles, and to integrate in vitro and in vivo data for presentations.
• Evaluate and implement innovative technologies and aid in developing strategies to evolve biotransformation capabilities and contribute to science through conference presentations and publication of new findings.

Basic Qualifications

• Bachelor’s Degree with 8+ years of academic and / or industry experience OR Master’s Degree with 6+ years of academic and / or industry experience OR PhD or equivalent advanced degree in the Life Sciences with 4+ years of academic and / or industry experience.

Preferred Qualifications

• A highly motivated individual with 4+ years of post-doctoral and/or industry experience directly related to the Key Responsibilities listed above (hands-on experience and in-depth knowledge of biotransformation and disposition).
• A significant advantage would be hands-on experience in application of the high-resolution mass spectrometry (HRMS) and NMR in “cold” in vivo metabolism studies including FIH, and strategies in 14C human ADME studies.
• Understanding of regulatory requirements in the areas of drug metabolism, drug-drug interactions, bioanalysis, toxicology, and clinical pharmacology
• Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skil