Scientist

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery

GENERAL SUMMARY:

The Scientist position in Biomarkers & Immunology department will be the technical subject matter expert and lab lead for the histology team, support biobank activities and cross train in molecular biology and other techniques.  This entails taking on challenging projects and completing them in a timely manner with focus on excellence and attention to detail.  These projects will include (but are not limited to) IHC/ISH/IF assay development and study execution, Visiopharm image analysis app development and data analysis/interpretation, biobank sample repository support and willingness to learn new methodology to support the BI team.  The Scientist will be expected to mentor and train junior team members in techniques and methods in which they have expertise.  Working closely with diverse groups on cross functional teams, (such as Early-Stage Product Development, Project Management, Clinical Sciences, and Clinical Development) our data deliverables impact important program decisions. 

This role will report to the Senior Director of Biomarkers and Immunology and be part of a talented, motivated, and creative team of scientists who are critical for the success of 4DMT’s mission and development of our deep portfolio of targeted genetic medicines. While on-site presence is required to perform laboratory work, a flexible hybrid work schedule can be accommodated when analyzing data and remotely managing partner organizations. 

MAJOR DUTIES & RESPONSIBILITIES:

• Independent method development of automated ISH/IHC/IF histology biomarker assays
• Independent sample testing design/execution/interpretation/reporting of diverse histology biomarker studies
• Visiopharm image analysis app development and execution
• Development of complex multiplex IF methodology
• Supporting internal biobiank project by receiving/accessioning, distributing and maintaining samples/inventories
• Cross-training with and supporting molecular biology and ligand binding assay subject matter experts
• Effective data summary and presentation to project teams and externally
• Leadership including cross training BI team members in areas of expertise
• Integration/participation in cross functional teams
• Leading and supporting research initiatives such as new technology development and platform improvement projects 
• Writing study reports and manuscripts and presenting results at scientific meetings 
• Maintaining compliance with company Environmental Health and Safety policies, procedures, and practices
• Contributing to building a culture that embraces continuous learning, improvement, and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise. 

QUALIFICATIONS: 

Education:

• Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field 
• Master’s degree with 2+ years, bachelor’s with 4+ years or PHD with 1+ years of experience

Experience:

• Immunohistochemistry automated assay development
• In situ hybridization automated assay development
• Experience in design and execution of complex image analysis using Visiopharm software
• Experience/troubleshooting common histology techniques (microtomy, grossing, embedding, H&E sta