Senior Manager, Portfolio Management & Operations

The Opportunity:

Revolution Medicines is seeking a motivated individual with experience in CMC, project and portfolio management, and/or life sciences management consulting to play a critical role within the Portfolio Management group of the Pharmaceutical Development and Manufacturing (PDM) organization. This position will serve as a key business partner supporting portfolio analytics, governance operations, resource and cost management, and strategic cross-functional initiatives. The role will partner closely with cross-functional stakeholders to drive execution of critical business processes, support decision-making, and improve organizational effectiveness across a growing portfolio of discovery, development, and commercial programs.

Responsibilities:

• Partner with PDM leadership and cross-functional stakeholders to support portfolio planning, business operations, and strategic decision-making across the organization.

• Develop analyses, insights, and recommendations that enable effective prioritization, resource allocation, risk management, and execution of business objectives.

• Drive cross-functional planning and governance activities by facilitating stakeholder alignment, supporting decision-making forums, and ensuring effective follow-through on key actions and commitments.

• Develop and maintain portfolio reporting, metrics, dashboards, and other decision-support tools to provide visibility into portfolio performance, organizational capacity, risks, and opportunities.

• Support budgeting and long-range planning activities through data analysis, scenario modeling, and business insight generation.

• Lead or contribute to strategic initiatives and operational excellence efforts aimed at improving business processes, organizational effectiveness, and scalability.

• Apply structured problem-solving and analytical approaches to address complex cross-functional challenges and support informed decision-making.

• Build strong partnerships across PDM and adjacent functions to promote transparency, alignment, and effective execution of key priorities.

• Prepare and deliver clear, concise, and compelling communications, presentations, and recommendations for audiences ranging from working teams to senior leadership.

Required Skills, Experience and Education:

• B.Sc. in a scientific, engineering, business, or related discipline, with 5+ years of experience within a CMC, Project and Portfolio Management, and/or life sciences management consulting organization.

• Robust analytical and problem-solving skills with experience in scenario planning, forecasting, resource modeling, and business analytics; demonstrated ability to translate analytical insights into executive-level communications.

• Strong scientific and business acumen with the ability to connect data, portfolio priorities, resource constraints, and organizational objectives into actionable recommendations.

• Demonstrated intellectual curiosity and learning agility, with a willingness to quickly develop expertise in new business processes, functional areas, and technical domains.

• Ability to influence without authority and build productive working relationships across functions and organizational levels.

• Exceptional communication and storytelling skills with the ability to synthesize complex information into clear, concise, and compelling recommendations for senior leadership.

• Demonstrated ability to balance strategic thinking with operational execution and deliver results across complex cross-functional initiatives.

• Demonstrated success operating in fast-paced, dynamic environments with evolving priorities and ambiguity.

• Proven track record of taking ownership, identifying opportunities for improvement, and proactively driving solutions with minimal direction.

• Strong project management and facilit