Senior Scientist, Translational Systems Toxicology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Nonclinical Safety

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Translational Systems Toxicology to be onsite in La Jolla, CA.
 

Purpose:
The Senior Scientist, Translational Systems Toxicology, will be part of the multi-disciplinary Translational Safety team in Preclinical Sciences and Translational Safety (PSTS) and will have first-hand involvement in the drug discovery process, from inception to clinic and beyond. This candidate will have an established track record using bioanalytical instrumentations primarily on proteomics and/or imaging mass spectrometry, with strong experience handling various cell and tissues samples.

You will be responsible for:

• Thoughtfully implement various arts of mass spectrometry (e.g., applying imaging, TOF, Orbitrap etc in both global and targeted acquisition modes) to support projects of multiple drug modalities such as small molecules, siRNA, PROTAC, Bispecific antibody, and CAR T-cell therapy.
• De novo methodology design and productive implementation, for studies using mass spectrometry, to ensure timely delivery.
• Initiate and perform hypothesis-driven investigation into mechanisms of toxicities.
• Work closely and be an avid contributor within the multi-disciplinary Translational Safety team to leverage expertise in cell & molecular biology, computational chemistry and biology.
• Be part of the evidence generation group by working closely with pathologists, toxicologists, DMPK and in vivo scientists to aid regulatory submissions and mitigate toxicology findings.
• Communicate study results and provide guidance to stakeholders in applying those results toward strategic decisions.
  
   

Qualifications / Requirements:

Education:

• Minimum of a Bachelor’s degree is required
• Advanced degree (Master's, PhD) in biochemistry, analytical chemistry or a related field is highly preferred
   

Required:

• Minimum 4-6 years of experience in the pharmaceutical industry/academia setting
• Able to independently design and perform proteomic approaches across different experiment types (global proteomic profiling, PTM, targeted and affinity MS analysis) using a variety of sample sources.
• Experience with several MS acquisition modes (e.g., DDA, DIA, PRM, MRM) and proteomic software.
• A track record of de novo mass spectrometry methodology design for both small and large molecules in complex biological samples.
• Proven record of scientific curiosity, creative thinking and a deep understanding of biology.
• Strong self-motivation and drive to make impactful contributions.
• Excellent analytical, communication and collaboration skills.
• Travel up to 10%, defined by business needs

Preferred:

• Demonstrated project team experience at a pharmaceutical company and ability to work effectively in a matrix, global environment as part of a multidisciplinary team.
• Ability to leverage large omics data sets
• First-hand experience with cell cultures (e.g., organoid & iPSC)
• Imaging mass spectrometry experiences
• Maintaining and troubleshooting nano/micro-flow liquid ch