Group Leader Assay R&D — Molecular Biology & Bioinformatics (NGS)

About MyOme
MyOme’s mission is to provide clinically actionable genetic information to patients throughout their lives. We combine clinical-grade whole genome sequencing, advanced methods for genome interpretation, and seamless digital tools for doctors and patients to order and access results. Our team is composed of seasoned entrepreneurs, scientists, and operators, and we're backed by top-tier investors.

Job Description
MyOme is seeking a group leader to lead NGS assay development with a focus on long read sequencing assays. This person will lead and scale an integrated team across molecular assay development, computational pipeline R&D with a company-wide impact. Proven experience in developing NGS-assays with bioinformatic workflows are essential. The ideal candidate will also be a decisive leader, capable of navigating ambiguous situations to deliver results.

Responsibilities:

• Technology Leadership

  • Design and optimize end-to-end targeted NGS workflows with assay team.

  • Institute stage gates on technology (R&D → Pre-Validation → Validation → Release).

  • Build robustness across sample types (whole blood, saliva) and throughput modes.

  • Work with Clinical Lab Operations to define analytical performance claims (LoD/LoQ, precision, specificity, interference/cross-reactivity, carryover) and verification/validation study designs.

  • Supervise team development of research analysis pipelines including definition of QC metrics acceptance criteria for successful development

  • Establish truth sets, simulation frameworks, and benchmarking (GIAB, contrived mixes)

  • Define analytical performance under real-world conditions.

  • Collaborate with downstream bioinformatics teams for production hand-off.

• Team Development

  • Recruit, mentor, and develop a high-performing team of R&D scientists

  • Foster a culture of collaboration, innovation, and accountability within the lab.

• Program Management

  • Maintain single integrated roadmap for assays, pipelines, automation, and data operations with quarterly milestones mapped to product releases

  • Budgetary responsibilities

• Publications

• Own the publication plan for assay components as well as IP strategy

• Opportunities to present at conferences, engage in external collaborations

Skills and Experience

• Ph.D. in Molecular Biology, Biochemistry, Genetics, Bioengineering, Computational Biology, or related field; equivalent experience considered.

• 8+ years in NGS assay/product development, with experience leading multi-disciplinary teams.

• Demonstrated record of targeted NGS assay launches or molecular diagnostics productization.

• Bioinformatics proficiency: Linux, Python/R; variant calling (SNV/indel/CNV/SV); Cloud compute.

• Experience with a range of NGS platforms (e.g. Illumina, ONT, PacBio).

• Demonstrated success scaling labs and data systems, including LIMS integration and automated QC release.

Location, Compensation, and Benefits

• Location: Onsite at our Menlo Park, CA laboratory campus. 

• Compensation: $170,000 - $230,000 per year, depending on experience, and the following benefits:

  • Company-paid health/vision/dental benefits

  • Equity

  • 401K

  • Unlimited PTO

  • Daytime schedule flexibility

  • Company-sponsored off-sites