Director, Portfolio & Program Strategy

The Role
Moderna is advancing its mRNA platform to unlock new therapeutic applications and expand its R&D portfolio across multiple disease areas. To maximize impact, the Portfolio & Program Strategy team plays a critical role in ensuring that portfolio investments are strategic, data-driven, and aligned with corporate priorities. This team operates across research, development and commercial functions to provide structured insights and enable executive decision-making.

The Director, Portfolio & Program Strategy, will be responsible for leading portfolio strategy projects and providing strategic investment recommendations. This individual will tackle Moderna’s most complex investment and prioritization questions, integrating scientific, financial, and strategic insights to drive high-impact decisions. As a strategic thought partner, they will ensure that portfolio and program strategies align with Moderna’s broader corporate objectives.

Here’s What You’ll Do

• Establish structured decision frameworks and processes to enable resource allocation, sequencing, and investment pacing based on real-time data and evolving priorities. 

• Partner with cross-functional teams (research, clinical development, commercial, manufacturing) to drive alignment on portfolio priorities, trade-offs, and strategic pivots.

• Assess the scientific, operational, and commercial impact of portfolio choices, ensuring enterprise-wide coordination while working closely with senior stakeholders. 

• Develop and refine portfolio models that integrate R&D attrition, clinical probability of success, commercial forecasts, and investment pacing to inform decision-making. 

• Deliver clear, data-driven insights and strategic recommendations to executive leadership, translating complex trade-offs into actionable, high-impact moves. 

• Continuously evaluate market, competitive, and internal pipeline dynamics to refine Moderna’s investment strategy.

Here’s What You’ll Need (Minimum Qualifications)

• 8+ years of experience in strategy, corporate development, or portfolio management within a clinical- or commercial-stage pharmaceutical/biotech company, or equivalent experience in management consulting (life-sciences focused), investment banking (healthcare sector) or venture capital (biotech/life sciences).

• Ability to perform and synthesize in-depth analyses of indications, products, and therapeutic areas, integrating findings into actionable recommendations.

• Advanced degree preferred (PhD, MD, PharmD, or MBA), with a strong understanding of drug development, R&D strategy, and value creation in biopharma.

• Demonstrated ability to work cross-functionally across research, clinical development, commercial, and manufacturing teams.

• Experience in portfolio modeling, scenario planning, or strategic investment frameworks.

Here’s What You’ll Bring to the Table (Preferred Qualifications)

• Advanced verbal and written communication skills to deliver a compelling narrative/message to senior stakeholders in the organization

• Experience in biopharma investment analysis, forecasting, or corporate strategy at a global level.

• Ability to translate scientific and financial trade-offs into executive-level decision-making insights.

• Familiarity with clinical trial design and regulatory pathways to understand pipeline development and market entry challenges.

• A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

• Highly competitive and inclusive medical, dental and vision coverage options
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
• Family care benefits, including subsidized back-up care options and on-demand tutoring
• Free premium access to fitness, nutrition, and mindfulness classes 
• Exclusive preferred pricing on Peloton fitness equipment
• Adoption and family-planning benefits
• Dedicated care coordination support for our LGBTQ+ community
• Generous paid time off, including:
  •    Vacation, sick time and holidays
  •    Volunteer time to participate within your community
  •    Discretionary year-end shutdown
  •    Paid sabbatical after 5 years; every 3 years thereaf