Senior Medical Science Liaison (California/U.S. Oncology)

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.

The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.

This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.

Your role

      Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)

      Scientific Exchange & External Engagement

• Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC
• Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy
• Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC

      Clinical Development & Trial Execution Support

• Support Tango-sponsored clinical trials, with emphasis on:
  • Site identification and activation
  • Enrollment support and investigator engagement
  • Ongoing scientific dialogue to enhance trial conduct
• Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams
• Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution

      Insight Generation & Strategic Contribution

• Capture and synthesize high-quality, hypothesis-driven insights from the field related to:
  • Trial design and execution
  • Competitive landscape
  • Future evidence needs
• Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness
• Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve

      Advisory Boards, Congresses & Scientific Presence

• Support planning and execution of advisory boards, investigator meetings, and other scientific forums
• Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology
• Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution

      Cross-Functional Collaboration & Compliance

• Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners
• Serve as a scientific resource to internal stakeholders
• Uphold the highest standards of compliance, scientific integrity, and ethical engagement

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