Principal Scientist, ADC Oncology Discovery Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission. ​

The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients.  The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus.  We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets.   We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.  We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary

We are seeking a creative scientist leader with experience independently leading antibody-drug conjugate (ADC) drug discovery teams from target concept to IND filing. The successful candidate will join the Discovery Biology ADC Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate should be a highly motivated, independent, interactive, and creative scientist capable of working across highly matrixed teams to advance drug discovery teams programs.

The successful candidate will be dedicated to leading matrixed ADC discovery project teams from the early stages/target concept all the way through to IND filing.

They will lead a team of scientists executing a wide range of biology bench studies, including developing and miniaturizing assays to enable the candidate discovery screening funnel and advancing the understanding of ADC mechanisms of action. In addition to leading candidate discovery and characterization efforts, the successful candidate will work with bioinformaticians and translational research scientists to design and execute work supporting patient stratification and identification of appropriate target engagement PD markers.

Position Responsibilities

In the role as a Principal Scientist within Discovery Biology, the ideal candidate will:

• Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation. 

• Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates

• Collaborate with functional area leads e.g. pharmacology, DMPK, informatics and predictive science to drive programs forward, including helping to define program priorities and risks.

• Apply extensive technical knowledge to address ADC mechanism of action

• Present complex concepts to a range of audiences including governance and f