Senior Research Associate/Associate Scientist, Biomolecular Interaction

Department: Lab Science

Employment Type: Full Time

Location: San Mateo, CA

Description

The Role: BigHat Biosciences is seeking a self-motivated individual for a Senior Research Associate or Associate Scientist role* in the Protein Sciences team to develop label-free assays for characterizing antigen-antibody interactions. Your position will interface regularly with the Discovery Medicine, Production, and Automation teams to support all aspects of biophysical characterization of antigen-antibody binding in a fast-paced and multidisciplinary environment. 

*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate. 

Key Responsibilities

• Design, develop, and perform kinetic experiments to study antigen-antibody interactions using label-free techniques
• Troubleshooting of kinetic experiments on both BLI and SPR platforms
• Perform epitope binning and quantitation experiments 
• Develop and onboard kinetic assays for screening antibodies in a high-throughput manner
• Write and transfer standard operating protocols (SOPs) for use on the Milliner Platform
• Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges
• Present experimental plans and results during regular meetings with manager and science teams

Skills Knowledge and Expertise

• B.S. with 5+ or M.S. with 3+ years of work experience in industry
• Experience using label-free biophysical techniques to study antigen-antibody interactions
• Extensive experience in developing, executing, troubleshooting SPR and BLI experiments for kinetics, quantitation, and epitope binning
• Good record keeping skills using LIMS and electronic notebooks
• Excited to work with diverse, cross functional teams to onboard new assays and disseminate results
• Prior experience with automation is preferred 

Compensation

For SRA: $[100 - 120]KFor Associate Scientist: $[120 - 140]K