Senior Scientist (Oligonucleotide Therapeutics)

We are seeking a highly skilled and motivated Senior Scientist to join our group dedicated to the drug discovery and technology development specifically in oligonucleotide therapeutics, such as antisense oligonucleotides and siRNAs. You will design and screen oligonucleotide candidates as well as carry out research on technology development to improve chemistry and delivery of nucleic acid therapeutics (siRNA/ASO). 

As a Senior Scientist, a typical day might include: 

• Maintaining and culturing cell lines and primary cells, as well as generating stable cell lines.

• Optimiassays to test oligonucleotide drug candidates such as siRNAs/ASOs using both cell-based activity assays (cell migration, viability, microscopy, flow cytometry, etc.) and RNA based activity assays (RT-qPCR, RISC loading, RNaseH cleavage)

• Running and analyzing off-target profiles, propose optimizations, and design PK/PD, stability and metabolic profiling assays

• Carrying out routine molecular biology and biochemistry tasks including PCR, western blot, etc.

• Optimizing and implementing protocols to test for novel delivery techniques for oligonucleotides based on antibodies, peptides and other conjugates

• Work on developing tissue specific delivery platforms for nucleic acid therapeutics

• Work closely with the synthetic chemistry group to optimize chemistry of nucleic acid drug candidates 

This role might be for you if you: 

• Have strong time-management skills, as well as attention to details and ability to innovate out of the box 

• Have the ability to multi-task and shift with changing priorities

• Are able to work efficiently both independently and as a part of the broader team

• Have excellent written and verbal communication skills

In order to be considered for this role, you must have at least a Ph.D. and 2+ years of relevant experience siRNA/gene therapy space. We need someone with experience working with siRNA/ASOs and an in-depth knowledge in gene transcription and protein translation, RNA splicing, as well as gene expression regulation. Experience in cell-based screening assays, such as ELISA, luciferase, fluorescence and Western blotting is required. Experience in flow cytometry and bDNA assays are highly preferred. We need someone with experience with cell culture and RT-qPCR skills. Experience working in-vivo and genotyping is a plus. Generating stable cell lines with various viral vectors (retrovirus, lentivirus, adeno-associated virus, etc) is strongly preferred. Experiences in bioconjugation, working with chromatography systems for biomolecule purifications are advantageous.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location.  In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.  For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together.  For that reason, many of Regeneron’s roles are required to be performed on-site.  Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.
 

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-bas