Senior Scientist I

Overview

Senior Scientist I is responsible to carry on advanced metabolite identification and elucidation, report writing in the metabolism-biotransformation function. Deliver high quality data in a timely fashion to support discovery, IND and late stage of development work. Able to perform complex trouble-shooting and problem-solving in the metabolism areas. Have the ability to implement new technologies and processes. Coordinate and work with other functions to deliver outstanding outcomes for assays/studies/projects in the field of drug discovery and development.

Responsibilities

• Perform the identification of drug metabolites by using liquid chromatography-tandem high-resolution accurate mass spectrometry, NMR, and other analytical methodologies independently.
• Independently elucidate metabolic pathways involving the identification and quantification of metabolites in biological matrices (e.g., blood, plasma, excreta) by using HPLC with radioactivity detection and LC-MS/MS.
• Design and conduct complicated in vivo and in vitro metabolism studies. Provides multiple approaches during the planning step.
• Familiar with modern LCMS and other analytical techniques for metabolite separation and identification and familiar with specialized metabolic profiling software.
• Work on complex problems in which assays of situations or data require an evaluation of intangible variables. Exercises independent judgment in developing methods, techniques and evaluation criteria for obtaining results
• Handle radio-labeled materials (e.g., 3H, 14C).
• Function as a study director, principal investigator, or project manager including serving as a primary contact for projects, responsibilities include planning, conducting and delivering projects in high quality and time fashion
• Familiar with regulatory guidance such as MIST guidance and acceptance criteria for discovery, IND and NDA stages of application.
• Maintain research notebooks in a well-organized manner.  All necessary documentation is recorded.
• Review other scientists’ calculations, records, and reports.
• Train, coach or mentor others on technical, personal development or business issues. Demonstrate good leadership through leading by example, motivation, and performance recognition.
• Write comprehensive reports, recommending application of findings, and present clear and concise oral reports of processes and accomplishments.
• Learn, enhance, and share technical knowledge of DMPK including ADME, PK, Metabolism, and Bioanalysis.
• Participate in writing and reviewing Standard Operating Procedures (SOPs), metabolism assay acceptance criteria and suggest practical changes. Comply with SOPs, guidelines and good housekeeping policies.
• Follow and promote company’s policies including safety policies, practices and procedures in order to maintain a safe work environment.
• Other duties as assigned.

Qualifications

• PhD, Master or bachelor’s degree in chemistry, Biology, or related science degree. PhD with 3+ years related experience.  Master’s degree with 10+ years related experience, Bachelor’s degree with 13+ years related experience or equivalent combination of education and/or work experience. 

Knowledge / Skills / Abilities:

• Strong knowledge and experience of experimental methods, concepts and techniques relevant to metabolite identification and profiling, such as in vivo/in vitro sample processing, method development and analysis, structure elucidation and metabolic pathways.
• Strong background in organic and analytical chemistry and extensive experience of interpreting complex mass spectrometry data.
• Familiarity with specialized metabolic profiling software.
• A good understanding of regulatory guidance like MIST guidance and acceptance criteria in discovery and development stages.
• Emerging skills in novel experimental methods, concepts and techniques
• Demonstrate independent thought and scientific creativity
• Demonstrate technical success and proficiency in projects
• Can independently propose and conduct research and develop new methodologies to implement and resolve complex problems
• Effective oral and written communication and interpersonal skills
• Good time management skills to perform multiple projects within timelines
• Ability to work in a team environment
• Follow and adhere to non-GLP guidelines/SOPs consistent with WuXi AppTec requirement

Physical Requirements: 

• Must be able to work in an office environment with minimal noise conditions.
• Must be able to work in Lab setting with exposure to biohazards / chemicals
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