Scientist I - Global Drug Discovery

About the Department                                                                                                                                               

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Seattle reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas. We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

 

The Position

The Scientist will provide technical leadership in complex in vitro and in vivo workflows, identification and validation of new drug targets, advancing novel therapies, and developing technologies to accelerate scientific research. This will be achieved by coordinating multiple research activities involving cross-functional project teams to ensure achievement of key deliverables. The Scientist will represent the organization to the external scientific community through publication and presentation of research, and through the development, management, and leadership of external collaborations. The individual will be seen across the company as a method/subject expert for one or two technologies or area(s) of biology.

 

Relationships

This is a full-time position in the Obesity, Diabetes and MASH Therapeutic Area at Novo Nordisk located in Lexington, MA, USA.

Internal relationships include working closely with technical staff & other members of the scientific leadership team; regular collaborations with members of other research departments in Boston; & frequent interaction with project managers & other colleagues in Denmark, Oxford and Beijing. Individual may be responsible for indirect reports or contingent workers.

Individual will interact with external research collaborators, both academia- & industry-based.

 

Essential Functions

• Design and perform in vitro and in vivo experiments for target ID, validation and MoA in the area of obesity and diabetes.
• Evaluate novel biology, methodologies, and implement new assays and platforms for target validation and investigation of pharmacological MoA.
• Support and drive drug discovery projects (target, biology, or technology-related)
• Generate new target ideas/hypotheses and propose experiments to mature the idea and validate the hypotheses for decision making
• Analyze and interpret complex data, drive conclusions, and next step. Present data and recommendation for next steps to cross-functional project teams.
• Evaluate novel biology, methodologies, and implement new assays and platforms for target validation and investigation of pharmacological MoA.
• Author internal reports, protocols, patents, external publications in peer-reviewed journals and presentations at external scientific conferences
• Maintain a strong understanding of theoretical knowledge and a connection to the external scientific community through continuous evaluation of relevant literature.
• Experience with in silico analyses and large datasets is highly desired.
• Author internal reports, protocols, and external publications.
• Effectively communicates and collaborates across global sites and guides project strategy by providing expert input to cross-functional project teams.
• Represent the organization at scientific conferences and global meetings by authorship and publication of scientific papers and patents.
• Maintain a strong understanding of theoretical knowle