Staff Scientist

Department

PSD Chemistry: He Group

About the Department

One of the first departments founded at the University of Chicago was the Department of Chemistry. Since then, The University of Chicago has been the recipient of more than 73 Nobel Prize recipients, 15 of which came from the Department of Chemistry. Our current faculty have considerable strength in inorganic, organic, and physical chemistry, as well as in interdisciplinary research that delves into biology, physics, and materials science.

Job Summary

The principal contribution of a Staff Scientist is leading translational research projects under mentorship of Dr. Chuan He in the Department of Chemistry. The He Lab group is looking for a highly experienced molecular biologist who has previous research experience in developing sequencing method for RNA and DNA modifications, and in DNA/RNA methylation and gene expression regulation. The Staff Scientist will work on research projects involving DNA/RNA modification profiling, high-throughput sequencing-based assays, new genomic method development, perform molecular biology experiments and coordinate lab research. The candidate needs to have a Ph.D. Degree in molecular biology and previous postdoc experience in molecular biology.

Responsibilities

• Perform routine and advanced molecular biology experiments, including nucleic acid extraction, purification, quantification, PCR/RT-PCR, and gel-based analysis.
• Prepare and process RNA and DNA samples for next-generation sequencing (NGS) workflows, including library preparation and QC steps.
• Support large-scale projects aimed at profiling DNA/RNA modification patterns across biological samples.
• Manage the development, optimization, and evaluation of new genomic and epitranscriptomic methods, including experimental troubleshooting and protocol refinement.
• Operates in a highly collaborative mode with all members of the group and with others in the Institute and with off-campus collaborators.
• Under general supervision of principal investigator, supervise and/or assist with the complex technical duties in a laboratory doing non-clinical research.
• Compile documents and assists with interpreting presentations or reports stemming from scientific contributions in the laboratory.
• Gives frequent internal and occasional external talks and tutorials on the thinking and work progress.
• Leads the contributions to scientific writing and publications, including protocols and grants.
• Mentor and supervise lab technician and undergraduate students within the group.
• Performs experiments and collects and analyzes data. Participates in the promotion of a research project.
• May present work at scientific meetings.
• Performs other related work as needed.

Minimum Qualifications

Education:

Minimum requirements include a PhD in related field.

Work Experience:

Minimum requirements include knowledge and skills developed through < 2 years of work experience in a related job discipline.

Certifications:

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Preferred Qualifications

Education:        

• PhD in Biology, Molecular Biology, or related field.

Experience:       

• Postdoc experience in molecular biology.

Technical Knowledge or Skills:

• Knowledge of basic computer proficiency including computer programs and standard laboratory equipment.
• Knowledge of relevant scientific fields.
• Knowledge of regulatory policies and procedures.

Preferred Competencies

• Demonstrated problem-solving, organization, analytical, and coordination skills including attention to detail.
• Demonstrated excellent oral and written communication skills.
• Demonstrated ability to read and comprehend scientific and technical literature, and methods to stay abreast of developments in the field.
• Ability to work independently and as a part of a team and interact with a diverse workforce.
• Ability to think creatively.
• Demonstrated ability to articulate their scientific discoveries both in written publications and in talks.

Working Conditions

• This is a full-time position based in a research laboratory environment. The role requires careful work, handling of biological samples, and adherence to laboratory safety practices.

Application Documents

• CV (required)
• References (preferred)

When applying, the