Senior Scientist– Cell Engineering and Paylod Delivery Process Development Onsite - Marlborough, MA

To drive the creation of new innovative biomanufacturing solutions, Sartorius has formed an initiative to discover new trends and cutting-edge opportunities for rapid conversion towards next generation continuous and integrated closed manufacturing solutions. This exciting initiative enables the research, process development and clinical production of novel modalities using next generation manufacturing platforms, in partnership with key customers.

Sartorius’ Process Development Services team in the Greater Boston (MA) area is a part of Corporate Research Group and is engaged in the design, development, and optimization of cell and gene therapy manufacturing processes that can be transformed from early pre-clinical stage into cGMP ready manufacturing scale. The incumbent is expected to work closely together with an internal multi-disciplinary product development team, to create forward looking processes that provide a basis for commercial manufacturing that can be integrated into our process solution offering. 

What you will accomplish together with us

• You will develop, and scale-up genetic cargo delivery for cell therapy manufacturing processes for multiple modalites including immune cells, iPSCs, vector packaging cell lines

• Establish critical process parameters that enable successful process scale-up

• You will identify critical quality attributes for successful production and develop assays to measure these CQAs

• Lead multiple high impact internal and external research projects by establishing priorities, milestones, schedules, and deadlines.

• Develop and write process development proposals, conduct hands-on laboratory work to optimize and troubleshoot upstream and downstream manufacturing processes for novel LNP formulations

• Responsible for writing, reviewing, and maintaining electronic lab notebooks with the highest level of research integrity.

• Responsible for writing project reports, briefs, protocols and making presentations to internal and external partners and project teams as required.

• Participate in technology transfer activities to internal and external collaborators.

• Support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.

• Conduct technical investigations and risk assessments related to manufacturing processes.

• Support generation of protocols, work instructions, batch records and reports.

• Work independently in a matrixed environment.

• Perform occasional extended hours and weekends to support ongoing lab activities as needed.

• Mentor and support junior staff and build a culture of support and collaboration.

• Comply with all site policies such as record retention, ISO requirements, and accountable for good housekeeping in all laboratories.

• Comply with biohazard, special clean room and site safety/health procedures and guidelines as required.

• Assist other team members and site management team with miscellaneous duties when requested.

What will convince us

• MS (with 2+ years of industry experience) or PhD in chemical, biochemical or biomedical engineering, engineered cell therapies or related field.

• Knowledge of current developments in genome editing and gene delivery technologies.

• Experience & knowledge of state-of the-art upstream and downstream technologies for cell therapy process development workflows.

• Ability to interface with specialists from target biological application areas and engineering disciplines such as mechanical (hardware, fluidic, thermal), electrical, software, sensor technology (optical, electronical), and chemical.

• Experience working as part of collaborative R&D project team.

• Strong analytical and mathematical ability.

• Ability to work independently and constructively in a team environment.

• Must have strong personal initiative and be result oriented.

• Strong troubleshooting skills

• Strong written and verbal English communication skills, capable of clearly expressing technical concepts to people with various levels of technical expertise and diverse cultural backgrounds.

• Identification with our core values: Sustainability, Openness, Enjoyment

• Working Conditions/Environment (ex. Any irregular or unusual work schedules, travel, etc):

Travel ~ 10-20% of time, both foreign and domestic. Work on weekends as required. Work in a Biosafety Level 2 Laboratory.

What We Offer

As a growing gl