Scientist – High Throughput Antibody Production

Do you have a passion for science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. 

About AstraZeneca in Waltham, MA: 

Our Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. It is filled with innovative technology. Our work areas were built to facilitate teamwork, interaction and cross functional science. We believe employees benefit from being challenged and inspired at work. As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release 

The Waltham site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. 

Summary of the Group 

Biologics Engineering (BE) is large global organization with team in Cambridge, UK and Gaithersburg MD responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. Our Waltham team is a new team we are building from the ground up to support both our global responsibilities as well as building an innovation center where we can push the boundaries of sciences and creativity. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs. 

Main Duties & Responsibilities 

We are seeking a skilled and highly motivated Scientist to enhance our High Throughput Production & Screening (HTPS) capabilities of biologics. The successful candidate will play a critical role in a dynamic group responsible for high throughput expression & purification of antibody therapeutics on a microgram-to-milligram scale and be an advocate for utilizing various automation platforms. The selected individual will be a well-organized and a highly productive scientist that can design and execute experiments efficiently, as well as analyze, interpret, and present data to multidisciplinary project teams. 

·       Collaborate and work with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects. 

·       Design, develop, and implement high throughput protein expression and purification workflows for various antibody like proteins.

·       Plan, execute, and complete high-throughput production and purification of protein therapeutics from mammalian expression systems using process automation and liquid handling robotics. 

·       Execute and analyze biochemical, biophysical, and functional profiling of antibodies, multispecifics, recom