Postdoctoral Fellow-MSH-13500-006

Title: Postdoctoral Fellow

Department: Surgery

Physical work location: (must be proper street address) Annenberg, 25th Fl, RM A25-70

Name PI or Supervisor: (include phone and email) David Sachs, 917-582-4676, david.sachs@mssm.edu

Web link to Lab: N/A (in process)

Web link to Department: https://www.mountsinai.org/care/surgery

Administrative Contact: (phone and email) Stella Cherepashensky, 212-241-7120, stella.cherepashensky@mountsinai.org

Details of Research Project: 

This research project in the Sachs laboratory focuses on the development of integrated human organoid and organ-on-chip models that combine cardiac, hepatic, and hematopoietic compartments, to study drug responses and disease mechanisms. Experimental approaches include 3D culture systems, microfluidic platforms, advanced imaging, and quantitative computational analysis. 

Technical Duties (include any protocols): 

This position requires expertise in human pluripotent stem cell culture and differentiation, 3D organoid culture, and microphysiological systems. Techniques include flow cytometry and cell sorting, immunofluorescence and confocal microscopy, qPCR and RNA-based analyses, protein assays, and functional phenotyping of cardiac, hepatic, and hematopoietic tissues. Responsibilities also include experimental design, data analysis, troubleshooting complex multi-lineage systems, and contributing to protocol development and optimization. Interaction with bioengineering collaborators and operation of automated or semi-automated culture systems. 

Technical Duties (include any protocols): 

This position requires expertise in human pluripotent stem cell culture and differentiation, 3D organoid culture, and microphysiological systems. Techniques include flow cytometry and cell sorting, immunofluorescence and confocal microscopy, qPCR and RNA-based analyses, protein assays, and functional phenotyping of cardiac, hepatic, and hematopoietic tissues. Responsibilities also include experimental design, data analysis, troubleshooting complex multi-lineage systems, and contributing to protocol development and optimization. Interaction with bioengineering collaborators and operation of automated or semi-automated culture systems. 

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affili