Senior Associate Scientist, Neuroscience

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attack neurodegenerative, neuromuscular and neuropsychiatric diseases.

Areas of interest include, but are not limited to, the following approaches:

Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Neuropsychiatric symptoms associated with neurodegenerative diseases; Emerging technologies (RNA targeting) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in neuromuscular diseases. Use approaches in cellular, preclinical and translational tools and technologies such as multiomics in tissue and fluid samples to identify novel biomarkers to track drug-target interactions and disease impact.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary:

The Senior Associate Scientist is a laboratory-based, integral member of the Neuroscience TRC (San Diego site) with a focus on research projects and small and large molecule asset support for a broad range of neurodegenerative indications. The successful applicant will leverage their experience in neuroscience/neuroimmunology and in vitro/ex vivo expertise, working collaboratively with other team members across disciplines to pharmacologically characterize target engagement and pharmacodynamics in CNS-relevant models such as ex vivo tissues, iPSCs/coculture systems and organoids. This position offers great potential for continued growth with exposure to all aspects of disease modelling and drug development and as such, in vivo experience would be considered advantageous. The Senior Associate Scientist will also be in a position to work on project teams across functions and sites and contribute to regulatory submissions.

The desired laboratory skills include cell and protein detection and familiarity with technologies such as flow cytometry, gene expression, various imaging techniques, ELISA and Simple Western.  The successful applicant should be comfortable with assay development, troubleshooting experimental procedures and data analysis and proficient in cell culture techniques, including conduct of assays to characterize molecules in iPSC-derived neural cells (mono-, bi- and tri-culture).  Good communication skills as well as strong teamwork and team-spirit are required.

Position Responsibilities:

In the role as a Senior Associate Scientist within the Neuroscience Preclinical Sciences group, the ideal candidate will be responsible for:

• Implementation and validation of assay systems in relevant cell types to screen and characterize the pharmacological responses to modulation with small and large molecules. 

• Development of assays in iPSC/cocultures/organoids with functional readouts that are relevant to the primary neurodegeneration indication and reflective of human genetics or epidemiology.

• Generate, record and report raw data and interpret to refine the next steps.

• Ensuring the proper documentation of all data in