Senior Scientist – Research Computational Biology (ARIA)

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist – Research Computational Biology (ARIA)

What you will do

Let’s do this. The ARIA Computational Biology team is seeking a talented and creative computational biologist to further our mission of serving patients by advancing and replenishing the Amgen therapeutic pipeline. In this role you will apply your expertise in data science and disease biology to accelerate the identification, prioritization, and validation of transformative therapeutic targets in a dynamic cross-functional research environment.

Focus areas include:

• Extracting biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses.
• Developing and leveraging methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities
• Innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships.
• Partnering with our data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a computational biologist with these qualifications.

Basic Qualifications:

Doctorate in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable]

Or

Master’s degree and 3 years of relevant research experience

Or

Bachelor’s degree and 5 years of relevant research experience

Preferred Qualifications:

• Strong programming skills (Python, R, Linux/Unix), familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g., Git).
• Track record of designing and implementing creative and holistic computational strategies to address challenging research questions.
• Demonstrated expertise in the analysis and interpretation of single cell omics data.
• Excellent presentation and communication skills to convey complex findings to diverse audiences.
• Self-starter with a collaborative mentality and a drive for continuous growth.
• Strong background in cardiometabolic disease and/or immunology, including application to the interpretation of single-cell data.
• Experience leveraging and fine-tuning transcriptional foundation models, LLMs, and biomedical knowledge graphs to further research goals.
• Familiarity with public data resources (e.g. DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M) frequently used to augment analyses of internally generated data.
• Experience developing and deploying tools and pipelines to endpoints such as interactive portals (e.g. RShiny apps), workflow management systems (e.g Nextflow), and agentic frameworks.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may includ