Senior Scientist 2, In Vivo Pharmacology - Endocrinology

Crinetics is a pharmaceutical company based in San Diego, California that develops much-needed therapies for people with rare endocrine diseases. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and robust pipeline across preclinical and clinical development. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier, fully integrated endocrine company from discovery to patients. Come join our team as we transform the lives of others.

Position Summary:

The Senior Scientist 2, In Vivo Pharmacology, will be responsible for providing in vivo support to our Endocrine Discovery teams, including designing, conducting, and interpreting experiments to demonstrate the efficacy and safety of novel small molecules in animal models.  The candidate will have a broad background in in vivo pharmacology and experience with in vivo disease models and non-GLP toxicology studies. 

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Design, conduct, and interpret in vivo experiments to evaluate the efficacy, pharmacokinetics, and safety of therapeutic candidate molecules in support of drug discovery programs with a focus on endocrine disease

• Conceive of, research, and develop new animal models of endocrine disease states

• Demonstrate a high level of initiative to oversee, troubleshoot, and accurately perform data analysis on in vivo studies

• Prepare protocols and reports and manage external CROs

• Analyze and present experimental data using Prism, Excel, MS Office, or comparable software

• Present findings to cross-functional internal groups, program team meetings, and at scientific conferences

• To serve as an in vivo pharmacology lead for Endocrine Discovery programs

• Lead and supervise junior scientists

• Responsible for ensuring compliance with company-established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards

• Perform timely data verification and ensure accuracy for laboratory notebooks, protocols, reports, and regulatory filings

• Willing to work some weekends and holidays as needed

Education and Experience:

Required:

• Ph.D. in Biology, Endocrinology, Pharmacology, Physiology, Toxicology, or related discipline with a minimum of 5+ years of relevant experience.

• Experience in designing and conducting rodent in vivo pharmacology and non-GLP toxicology studies

• Experience working in the pharmaceutical industry

• Experience writing protocols, validation packages, and reports to support IND filings is a plus.

• Hands-on proficiency in rodent handling procedures and in vivo skills, including dosing (IV, PO, SC), blood and tissue collection, necropsy, etc.

• Proficiency with basic surgical techniques

• Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature

• Experience managing and supervising research associates and junior scientists.

• Able to effectively communicate and present summaries of research results to team members and colleagues from other disciplines

• Must have a strong work ethic and be enthusiastic about animal and laboratory work

• Must be detail-oriented, punctual, reliable, and available on weekends when necessary

• Excellent written and verbal communication skills, with the ability to collaborate effectively in a multidisciplinary team environment.

• Ability to work in a fast-paced environment and adapt to change

Preferred:

• Experience developing endocrinology in vivo models

• Experience managing direct reports

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functi