Senior Director, Clinical Practice Liaisons

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

The Sr. Director, Clinical Practice Liaison (CPL) is a key field-based leadership position responsible for the strategic and tactical oversight of the CPL team within a defined U.S. region. This individual will play a critical role in managing and developing CPLs, ensuring the team executes against the company’s medical strategy, complies with regulatory and internal policies, and delivers scientific value to both internal and external stakeholders. 

This position will interface regularly and compliantly with cross-functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including Thought Leaders (TL), healthcare decision-makers, and other relevant stakeholders. 

Key Responsibilities 

•  Team Leadership & Development 

• Recruit, coach, and manage performance of regional CPLs 

•  Foster continuous development through mentoring and training 

• Align CPL activities with strategic objectives and tactical plans 

• Medical Strategy Execution 

• Drive implementation of regional field medical strategies 

• Translate national objectives into actionable, regionally tailored activities 

•  Partner with cross-functional teams to integrate field insights into medical planning 

• Cross-functional Collaboration 

• Collaborate closely with Sales, Marketing, Market Access, and Clinical Operations 

• Serve as a field-based liaison for HQ Medical Affairs initiatives 

• Contribute to launch readiness and lifecycle management strategies 

• Clinical Trial Support 

• Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs 

• Congress & External Engagement 

• Represent Medical Affairs at U.S. medical congresses in a compliant manner 

• Coordinate booth planning, scientific exchange, competitive intelligence, and post-conference debriefs 

• Strategic Team Building 

• Contribute to the design and structure of the U.S. Field Medical team 

• Identify evolving business needs and adjust regional capabilities accordingly 

• Compliance & Quality 

• Ensure all CPL activities comply with company SOPs, industry standards, and applicable regulations 

• Uphold the highest ethical standards in all external engagements 

• Travel Requirement 

• Willingness to travel 25–75% for congresses, site visits, and stakeholder engagement  

Qualifications & Experience 

•  Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.)  

• Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)  

• Minimum 3 years of people management experience or formal leadership development participation 

• In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health, or MASH/NASH preferred 

• Proven ability to understand, communicate, and translate complex scientific information 

• Strong knowledge of U.S. healthcare system, FDA regulations, and medical affairs compliance standards 

• Demonstrated cross-functional collaboration, project execution, and strategic planning skills 

• Proficiency in Microsoft Office Suite, virtual communication platforms (e.g., Zoom), and CRM systems (e.g., Veeva)   

Preferred Attributes 

• Strong interpersonal, presentation, and relationship-building skills 

• Adaptable and proactive in a fast-paced, evolving environment 

• Passion for