Associate Scientist, Molecular Biology, Next-Generation Sequencing, and Assay Development

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The Protein Homeostasis Thematic Research Center at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.

Position Summary:

The Sequencing Research & Genomics (SRG) group at Bristol Myers Squibb (BMS) is seeking a conscientious, highly motivated, and detail-oriented Associate Scientist with experience in molecular biology, next-generation sequencing, and laboratory automation. This role offers an exciting opportunity to contribute to the development, optimization, and implementation of genomics workflows that support early drug discovery program advancement.

As part of the Protein Homeostasis Thematic Research Center, the successful candidate will work in a collaborative, cross-functional environment focused on enabling high-quality, reproducible, and scalable genomics technologies. The candidate will support hands-on laboratory execution across nucleic acid extraction, NGS library preparation, sample QC, sequencer loading, and automation-enabled workflow development. This position is well suited for a technically strong scientist who enjoys meticulous experimental work, operational rigor, protocol refinement, and the translation of manual molecular biology workflows onto automated liquid handling platforms.

The candidate will contribute to SRG’s mission of enabling high-quality genomic data generation across diverse biological systems and project teams, helping advance scientific understanding of disease biology and therapeutic hypotheses with line of sight to patient impact.

Position Responsibilities

In the role as an Associate Scientist within the Sequencing Research & Genomics team, the ideal candidate will:

• Support NGS laboratory operations by performing RNA and DNA extraction, nucleic acid purification, sample normalization, NGS library preparation, library QC, pooling, and sequencer loading across established genomics workflows.

• Execute molecular biology and NGS workflows with strong technical rigor, including DNA-Seq, RNA-Seq, targeted sequencing, amplicon-based workflows, and other sequencing-based assays as needed to support research programs.

• Contribute to automation-enabled workflow development by supporting the transfer, optimization, and benchmarking of manual molecular biology and NGS protocols onto automated liquid handling platforms.

• Operate, maintain, and troubleshoot automated liquid handling systems in collaboration with team members and automation partners, ensuring reliable execution of routine and developing workflows.

• Participate in assay optimization and technology benchmarking, including testing workflow modifications, assessing assay performance, comparing manual and automated approaches, and contributing to continuous improvement of throughput, reproducibility, and data quality.

• Develop, revise, and maintain protocols and SOPs, ensuring methods are clearly documented, reproducible, and aligned with evolving laboratory best practices.

• Generate, organize, and maintain meticulous experimental records, including sample information, protocol versions, instrument runs, QC metrics, deviations, troubleshooting notes, and workflow outcomes.

• Analyze, summarize, and interpret experimental results in collaboration with team members, and prepare clear data summaries, figures, tables, and writte