Scientist, Cell Line Development, CHO Protein Vaccines

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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

GSK Vaccines is seeking a highly motivated scientist to join the Mammalian Expression Technologies Center of Excellence (MET CoE). Based in Cambridge, MA, this role is focused on the early development of production cell lines and genome engineering techniques to support platform innovation for recombinant protein-based vaccines. This position will play a significant role in shaping GSK’s vaccine pipeline to address unmet medical needs and accelerate global health initiatives. This is an exciting opportunity to integrate with a diverse group of talented industry experts, lead key cell line development activities, and further progress in your career.

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Main Responsibilities:

• Hands-on development of commercial CHO cell lines for recombinant protein-based vaccines by harnessing the understanding of cell x molecule x process
• Key contributor toward the design and implementation of new technologies and genome engineering strategies to support next-generation CHO platform innovation.
• Work effectively in a team environment to interpret project results and contribute to technical discussions by effectively communicating key updates to collaborators and team members.
• Maintain accurate and detailed laboratory notebooks and electronic records (e.g., SOPs, batch records, and reports) in compliance with company policies and current cGMP (related to raw material control strategies and cell line derivation) for accelerated CMC submissions.

Basic Qualifications:

• PhD, MS, or BS degree in Biochemistry, Cell Biology, Molecular Biology, Bioengineering or relevant fields with 1+ (PhD), 3+ (MS), or 5+(BS) years relevant experience within a pharmaceutical or biotech industry, respectively.
• One or more years of experience in developing stable mammalian cell lines for use in manufacturing (CHO preferred).
• One or more years of experience with analytical assays such as PCR, qPCR, ddPCR, Octet, and Western blot.
• One or more years of experience using genome editing tools (such as CRISPR and transposases) to modify mammalian cell lines.

Preferred Qualifications:

• Working understanding of US/EU regulatory requirements for CMC biologics development.
• Ability to embed advanced analytics (AI/ML) and data sciences to drive platform development and move to predictive in-silico design.
• Dedicated team player with a collaborative mindset to support cross-functional knowledge sharing.
• Proficiency with Microsoft Excel or statistical analysis software (JMP, Prism, etc.) for analyzing and presenting data.
• Ability to think critically, analytically, and demonstrate strong troubleshooting and problem-solving skills based on deductive reasoning.
• Ability to design and implement experiments with minimal technical supervision.
• Strong organizational and time management skills with the ability to prioritize and manage multiple tasks/project activities simultaneously.

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Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat dise