Senior Scientist, High Throughput Biology

Job Description Summary

The Discovery Sciences (DSc) department within Novartis Biomedical Research (BR) in Cambridge, MA, has an exciting opportunity for a B.S. or M.S. level scientist. In this role, you will be part of a team focused on early drug discovery. Your primary responsibilities will be to develop disease-relevant cell-based and/or biochemical assays used in the context of mid-size to large screening campaigns to identify chemical starting points or targets for novel drug discovery programs.

 

Job Description

Internal Job Title: Senior Scientist I/Senior Scientist II

Position Location: Cambridge, MA, onsite, no travel required

About this role:

The Discovery Sciences (DSc) department within Novartis Biomedical Research (BR) in Cambridge, MA, has an exciting opportunity for a B.S. or M.S. level scientist. In this role, you will be part of a team focused on early drug discovery. Your primary responsibilities will be to develop disease-relevant cell-based and/or biochemical assays used in the context of mid-size to large screening campaigns to identify chemical starting points or targets for novel drug discovery programs.

Your responsibilities include, but are not limited to:

• Develop and optimize biochemical and cellular assays for hit compound identification and characterization with a high-throughput screening mindset and execute mid to large screens using compounds or genetic reagents for drug/target discovery.
• Perform mechanism-of-action studies using cell biology, molecular biology/genetics, and signaling approaches.
• Engage with multidisciplinary project teams to design, execute, analyze, document experiments and communicate results in team settings.

• Collaborate across departments and with external partners to foster growth and innovation within the team and department, and contribute to the culture of the group, are key aspects of this role
• Develop relationships with stakeholders and collaborators and represent Novartis values of transparency, integrity, courage, innovation, quality and collaboration.

Minimum requirements:

• B.S. or M.S. degree in biological sciences, Biochemistry, Molecular Biology, Chemical Biology or related fields with 4+ years of hands-on research experience in mammalian cell biology and biochemistry, preferably in industry.
• Proficiency in biochemical and cellular assay development, high-throughput screening, automation, and high content imaging.
• Experience working with, troubleshooting, and protocol development with automated and semi-automated devices including liquid handling, acoustic transfer, plate washing, imaging, fluorescence and luminescence plate readers and automated laboratory scheduling software including High-Res Biosystems Cellario and BioSero Green Button Go.
• Candidate should enjoy working in a collaborative team environment and be able to handle multiple tasks efficiently as well as troubleshoot problems.
• Excellent oral and written communication skills.

Desirable Skills:

• Knowledge in mammalian cell culture and molecular biology techniques including transfection, viral transduction, Western blotting, and CRISPR.
• Ability to handle large data sets, and familiarity with GraphPad Prism, Microsoft Excel/Word/PowerPoint and Spotfire.

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment pra